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YAP

YAP

YAP (Yes-associated protein) regulates cell growth, tissue homeostasis, and organ size as a transcription co-activator in the Hippo tumor suppressor pathway. The kinase Lats inhibits YAP by phosphorylating it, causing it to localize to the cytoplasm and be degraded by proteasomes. By attaching to transcription factors from the TEAD family, YAP stimulates the expression of genes.

YAP has a complicated role in human cancer that may vary depending on the cell type. For instance, by inducing apoptosis in response to DNA damage, YAP may act as a tumor suppressor in some cell types, such as hematological cancers.

YAP related products

Structure Cat No. Product Name CAS No. Product Description
TEAD-IN-14 V88146 TEAD-IN-14 TEAD-IN-14 (75a) is an orally active TEAD inhibitor with IC50 of <100 nM and half-life of 2.3 h in mice.
TEAD-IN-16 V88152 TEAD-IN-16 TEAD-IN-16 (compound BC-011) is a potent inhibitor of TEAD with IC50 of 72.43 μM.
TEAD-IN-19 V145713 TEAD-IN-19 TEAD-IN-19 is a TEAD transcriptional inhibitor that, at a concentration of 10 μM, inhibited TEAD1, TEAD2, TEAD3, and TEAD4 by 38.5%, 36.2%, 57.8%, and 71.3%, respectively.
TEAD-IN-20 V145714 TEAD-IN-20 3007592-85-7 TEAD-IN-20 is a TEAD inhibitor.
TEAD-IN-21 V118301 TEAD-IN-21 TEAD-IN-21 is a highly effective, orally administered pan-TEAD inhibitor with an IC50 value of 3 nM.
TEAD-IN-22 V116908 TEAD-IN-22 3034813-65-2 TEAD-IN-22 (compound I) is a TEAD inhibitor.
TEAD-IN-23 V113872 TEAD-IN-23 3074990-47-6 TEAD-IN-23 (compound 22) is a potent pan-TEAD inhibitor with an IC50 value of 10 nM.
TEAD-IN-24 V112278 TEAD-IN-24 3034813-75-4 TEAD-IN-24 (Example 65) is a TEAD inhibitor.
TEAD-IN-6 V69183 TEAD-IN-6 2821763-12-4 TEAD-IN-6 (Example 11-1) is a TEAD modulator that blocks the interaction between YAP1/TAZ and TEAD.
TEAD-IN-8 V84549 TEAD-IN-8 1008768-41-9
TEAD-IN-9 V88144 TEAD-IN-9 TEAD-IN-9 (compound 17) is a TEAD1 inhibitor with IC50 of 0.29 μM.
TEAD1/3/4-IN-1 V145712 TEAD1/3/4-IN-1 2762619-63-4 TEAD1/3/4-IN-1 is an orally effective TEAD1/3/4 inhibitor.
TED-347 V38733 TED-347 2378626-29-8 TED-347 (TED347) is a novel,covalent/irreversible,and allostericYAP-TEAD protein-protein interaction inhibitor with anticancer activity.
TRULI (Lats-IN-1) V69174 TRULI (Lats-IN-1) 1424635-83-5 TRULI (Lats-IN-1) is a potent, ATP-competitive inhibitor of Lats1 and Lats2 kinases.
TT-10 (TAZ-K) V69178 TT-10 (TAZ-K) 2230640-94-3 TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcription enhancer domain (TEAD) activity.
Tubulin polymerization-IN-79 V146628 Tubulin polymerization-IN-79 Tubulin polymerization-IN-79 is a microtubule polymerization inhibitor.
USP10-IN-4 V119138 USP10-IN-4 USP10-IN-4 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with an IC50 of 10.87 μM and a Kd of 365 nM.
Verteporfin liposome V146949 Verteporfin liposome Verteporfin liposome is the liposome-encapsulated form of verteporfin.
VS3 V111093 VS3 2576427-49-9 VS3 is a YAP-TEAD interaction inhibitor.
VT02956 V76351 VT02956 2999763-09-4 VT02956 is a LATS inhibitor (IC50= 0.76 nM for LATS1 and 0.52 nM for LATS2).
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