The -phosphate group of ATP is transferred to protein substrates by the Ser/Thr phosphoryl transferase known as PKA. More than 100 membrane- and cytoplasmic-associated targets are phosphorylated by PKA. PKA mediates a wide range of cellular signaling activities, and its activity is strictly controlled in both time and space.
The hedgehog (Hh) signal transduction pathway is negatively regulated by PKA, an evolutionary conserved protein. The proteolytic processing step that results in the repressor forms of the Ci and Gli transcription factors, which turn off target genes in the absence of Hh, is known to require PKA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69112 | 6-Bnz-cAMP sodium salt | 1135306-29-4 | 6-Bnz-cAMP sodium salt is a cell-permeable (penetrable) cAMP analog. |
|
V1847 | 8-Bromo-cAMP | 76939-46-3 | 8-Bromo-cAMP is a potent and cell permeable cyclic AMP (cAMP) analog and a PKA activator. |
|
V78101 | Aplithianines A | Aplithianines A is a potent J-PKAcα inhibitor (antagonist) with IC50 of 1 μM and IC50 of 84 nM against wild-type PKA. | |
|
V78154 | ATP Synthesis-IN-3 | ATP Synthesis-IN-3 (compound 31) is an ATP hydrolysis inhibitor and has a protective effect during myocardial ischemia. | |
|
V69118 | BLU0588 | 2810747-78-3 | BLU0588 is an orally potent and specific PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor (antagonist) with IC50 of 1 nM and a dissociation constant (Kd) of 4 nM. |
|
V4272 | Bucladesine calcium (DC2797) | 938448-87-4 | Bucladesine calcium (Dibutyryl-cAMP calcium; DC2797 calcium salt) is a cell-permeable PKA activator/agonist and a cAMP analog that mimics the action of endogenous cAMP. |
|
V2841 | CCG215022 | 1813527-81-9 | CCG215022 is a potent GRK2 and GRK5 inhibitor that exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA. |
|
V69124 | Cys-Kemptide | 309247-46-9 | Cys-Kemptide is a cysteine-terminated substrate peptide that may be utilized to measure protein kinase A (PKA) activity. |
|
V1846 | Dibutyryl-cAMP (Bucladesine sodium) | 16980-89-5 | Bucladesine sodium (also known as Dibutyryl-cAMP sodium), the sodium salt ofBucladesine, is a cell-permeable PKA activator and a cAMP analog that mimics the action of endogenous cAMP. |
|
V69111 | DS89002333 | 2832159-79-0 | DS89002333 is an orally bioavailable and potent PRKACA inhibitor (antagonist) with IC50 of 0.3 nM. |
|
V69106 | GEM-231 (HYBO-165) | 255810-66-3 | GEM231 is an antisense oligonucleotide targeting PKA-I (RIα regulatory subunit of cAMP-dependent protein kinase type I) mRNA. |
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V79571 | GEM-231 sodium (HYBO-165 sodium) | GEM231 sodium is an antisense oligonucleotide targeting PKA-I (RIα regulatory subunit of cAMP-dependent protein kinase type I) mRNA. | |
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V16050 | H-89 free base | 127243-85-0 | H-89 is a specific adenylyl cyclase inhibitor (DDA) and a cyclic AMP-dependent protein kinase inhibitor. |
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V31529 | Jaspamycin | 22242-96-2 | Jaspamycin(7-CN-7-C-Ino) is a naturally occuring metaboliteisolated from the marine sponge Jaspis splendens with anti-parasiteactivity. |
|
V80487 | Kemptide Phospho-Ser5 (Kemptide (Phospho-Ser5)) | Kemptide (Phospho-Ser5) is a phosphoacceptor peptide and a specific substrate of cyclic adenosine monophosphate-dependent protein kinase A (PKA). | |
|
V69119 | PKA Inhibitor Fragment (6-22) amide (PKI-(6-22)-amide) | 121932-06-7 | PKA Inhibitor Fragment (6-22) amide is an inhibitor (blocker/antagonist) of cAMP-dependent protein kinase A (PKA) with a Ki of 2.8 nM. |
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V76627 | PKA Inhibitor Fragment (6-22) amide TFA (PKI-(6-22)-amide TFA) | PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor (blocker/antagonist) of cAMP-dependent protein kinase A (PKA) with a Ki of 2.8 nM. | |
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V69109 | PKA-IN-1 | 179985-52-5 | PKA-IN-1 is a highly efficient and selective inhibitor of cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) with IC50 of 0.03 μM. |
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V69113 | PKI (14-24)amide TFA | 1293946-39-0 | PKI (14-24)amide TFA is a potent PKA inhibitor. |
|
V69120 | PKI (5-24),amide (IP20-amide) | 100891-36-9 | PKI (5-24),amide (IP20-amide) is a 20-residue peptide corresponding to the active portion of the thermostable inhibitory protein of cAMP-dependent protein kinase. |
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