Animal organ size is regulated by the Hippo signaling pathway, also referred to as the Salvador/Warts/Hippo (SWH) pathway, through the control of cell proliferation and apoptosis. The protein kinase Warts (Wts) is phosphorylated by Hpo in the Hippo pathway's core kinase cascade. Hpo is a protein kinase belonging to the Ste-20 family (also known as MST1/2 in mammals). Cell proliferation, apoptosis, and different stress reactions are among the cellular processes that this highly conserved group of serine/threonine kinases controls.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V41374 | I3MT-3 | 459420-09-8 | I3MT-3 (also known as HMPSNE; EMT inhibitor-1;EMT inhibitor 1) is a novel, selective, potent, and membrane permeable inhibitor of 3MST (3-Mercaptopyruvate sulfurtransferase) with IC50 of 2.7 μM. |
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V2017 | XMU-MP-1 | 2061980-01-4 | XMU-MP-1 is a potent,reversible and selective inhibitor of MST1/2 with IC50 values of 71.1 nM and 38.1 nM against MST1 and MST2, respectively. |
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