TRP Channel

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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TRP Channel

TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.

TRP Channel related products

Cat No.	Product Name	CAS No.	Product Description
V117549	FP802	61694-81-3	FP802 is an orally effective and potent TwinF interface inhibitor that can disrupt and neutralize the toxicity of the NMDAR/TRPM4 death complex.
V114795	FP802 dihydrochloride	2490401-57-3	FP802 hydrochloride is an orally effective and potent TwinF interface inhibitor that can disrupt and neutralize the toxicity of the NMDAR/TRPM4 death complex.
V70135	GDC-0334	1984824-54-5	GDC-0334 is a TRPA1 selective antagonist.
V70128	GDC-6599	2376824-99-4	GDC-6599 (Example 8) is an orally bioavailable TRPA1 inhibitor.
V40197	GFB-8438	2304549-73-1	GFB-8438 is a novel, highly potent and subtype specific TRPC5 inhibitor with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively.
V136725	Glucoputranjivin	18432-16-1	Glucoputranjivin is a reference compound that can be used for the qualitative and quantitative determination of active compounds in SO₂.
V3576	GSK1016790A	942206-85-1	GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) activator.
V3556	GSK2193874	1336960-13-4	GSK2193874 (GSK-2193874) is a novel, potent, orally bioactive, and selectiveTRPV4 (Transient Receptor Potential Vanilloid 4)antagonist with the potential to be used forcongestive heart failure.
V136953	GSK2220691	1206619-37-5	GSK2220691 is a potent TRPV4 inhibitor.
V136963	GSK3527497	2215855-22-2	GSK3527497 is an orally effective TRPV4 inhibitor.
V107521	HC-067047 hydrochloride	1481646-76-7	HC-067047 hydrochloride is a potent and selective TRPV4 antagonist that reversibly inhibits currents of human, rat, and mouse TRPV4 homologues with IC50 values of 48 nM, 133 nM, and 17 nM, respectively.
V22085	HC-070	1628291-95-1	HC-070 is a novel and potent inhibitor of TRPC4 and TRPC5 with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cell assay.
V87245	hTRPA1-IN-1		hTRPA1-IN-1 (19), a sesquiterpenoid isolated from the sea sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential cation channel phalloidin 1 (TRPA1) with an IC50 of 2 μM.
V70130	Hyp9	3118-34-1	Hyp9 is a transient receptor potential cation channel 6 (TRPC6) specific agonist.
V137733	HZS60	3027529-88-7	HZS60 is a brain-penetrating NMDAR/TRPM4 inhibitor that can improve cerebral ischemia.
V2999	Icilin	36945-98-9	Icilin (also known as AG-3-5 or AG 3-5) is a synthetic CMR1/TRPM8 (transient receptor potential M8) super-cooling agent/agonist that is 2.5-fold more efficacious and nearly 200-fold more potent than the reference cold thermosensory agonist, l-menthol.
V70155	JNJ-28583113	2765255-93-2	JNJ-28583113 is a brain-permeable (penetrable) TRPM2 antagonist.
V116031	JNJ-38893777	951135-00-5	JNJ-38893777 is an orally effective, highly selective transient receptor potential capsaicin type 1 (TRPV1) channel antagonist.
V94847	JW-65	2763378-71-6	JW-65 (Compound 20) is a TRPC3 inhibitor.
V111545	JYL-273 analog-1	289902-71-2	JYL-273 analog-1 (compound 28, Example 45) is a potent transient receptor potential ion channel (TRP channel) (TRPV1) agonist (Ki = 10.8 nM).