TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V5910 | BCTC | 393514-24-4 | BCTC is a selective and orally bioactive vanilloid receptor 1 (TRPV1 receptor) antagonist. |
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V129955 | BD-1063 | 150208-28-9 | BD-1063 is a selective σ-1 receptor antagonist with inhibitory activity against TRPC5 and TRPM3. |
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V4712 | BI-749327 | 2361241-23-6 | BI-749327 (BI749327) is a novel, potent and orally bioavailableantagonist of Transient receptor potential canonical type 6 (TRPC6) with the potential to be used for treating PAH (pulmonary arterial hypertension) and PH (pulmonary hypertension) due to respiratory diseases or hypoxemia. |
|
V70154 | Bisandrographolide A (BAA) | 160498-00-0 | Bisandrographolide A (BAA) activates TRPV4 channels with EC50 of 790-950 nM. |
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V70149 | Bisandrographolide C (Bisandrographolide C) | 160498-02-2 | Bisandrographolide C is a unique dimer isolated and identified from Andrographis paniculata. |
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V100603 | BTB 06061 | 652967-47-0 | BTB 06061 is a TRPM7 inhibitor that can be used in the study of ischemic diseases. |
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V70166 | Capsiate | 205687-01-0 | Capsiate is a capsaicin analog derived from the CH-19 non-irritating sweet red pepper variety and is an orally bioactive TRPV1 agonist. |
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V70137 | Capsiconiate (Coniferyl (E)-8-methyl-6-nonenoate) | 946572-73-2 | Capsiconiate (Coniferyl (E)-8-methyl-6-nonenoate) is a TRPV1 agonist (EC50= 3.2 μM). |
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V78708 | CEDAEVFKDSMVPGEK | CEDAEVFKDSMVPGEK is a rat capsaicin receptor subtype 1 (VR1) peptide sequence fragment that may be utilized to detect the presence, distribution and molecular morphology of VR1. | |
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V79956 | Clemizole-d4 | Clemizole-d4 is a deuterated form of Clemizole. | |
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V104959 | CMP233 | 307001-06-5 | CMP233 is a potent TRPM4 antagonist with IC50 of 0.15 μM. |
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V101676 | Cyclo(-asp-gly) | 52661-97-9 | Cyclo(-asp-gly) is a cyclic dipeptide composed of amino acids and a potential TRPV1 stimulator. |
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V70161 | D-erythro-Sphingosine hydrochloride (Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride) | 2673-72-5 | D-erythro-Sphingosine (Erythrosphingosine) HCl is a specific TRPM3 activator. |
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V70172 | Dihydrocapsiate | 205687-03-2 | Dihydrocapsiate, a compound of the dihydrocapsinoid family, is an orally bioactive TRPV1 agonist. |
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V70144 | Diisopropyl adipate (Adipic acid diisopropyl ester) | 6938-94-9 | Diisopropyl adipate is an alternative plasticizer and TRPA1 activator. |
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V104221 | DWP-05195 | 904309-12-2 | DWP-05195 is a TRPV1 antagonist that inhibits pain signaling. |
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V135026 | ELP-004 | 15533-81-0 | ELP-004 is a TRPC channel inhibitor that inhibits TRPC channel-mediated Ca2+ influx. |
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V135227 | ErSO-TFPy | 3035547-78-2 | ErSO-TFPy is an ERα+ tumor cell inhibitor that exhibits low nanomolar cytotoxic activity against ERα+ breast cancer cells. |
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V135281 | Estradiol 3-methyl ether | 1035-77-4 | Estradiol 3-methyl ether is a highly selective TRPML1 ion channel antagonist and microtubule depolymerizer with IC50 values of 0.22 μM and 3.8 μM for TRPML1 and TRPML2, respectively; it is inactive for TRPML3. |
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V70117 | Evifacotrep | 2413739-88-3 | Evfacotrep is a short-term transient receptor potential channel 5 (TRPC5) antagonist (WO2020061162, compound 100) that may be utilized in the study of neurological diseases. |
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