TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V127425 | 6-Iodonordihydrocapsaicin | 859171-97-4 | 6-Iodonordihydrocapsaicin is a TRPV1 antagonist. |
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V127653 | 8,9-Epoxyeicosatrienoic acid | 81246-85-7 | 8,9-Epoxyeicosatetrienoic acid has a unique protective effect on the glomeruli. |
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V92298 | 8-Br-7-CH-ADPR | 1011457-95-6 | 8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. |
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V127753 | 8-Br-ADPR disodium | 8-Br-ADPR disodium is a TRPM2 inhibitor and ADPR signaling pathway antagonist. | |
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V101253 | 8-Br-cADPR | 151898-26-9 | 8-Br-cADPR is a potent cADPR antagonist. |
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V127754 | 8-Br-cADPR sodium salt | 8-Br-cADPR sodium salt is a cyclic adenosine diphosphate (ADP)-ribose (cADPR) antagonist and also a TRPM2 ion channel antagonist. | |
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V93737 | A-889425 | 1072921-02-8 | A-889425 is an orally active, selective TRPV1 receptor antagonist with IC50 values of 335 nM (rat) and 34 nM (human). |
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V6545 | A-967079 | 1170613-55-4 | A-967079 is a novel, potent, CNS-penetrant and selective blocker/antagonist TRPA1 channel (IC50s of 67 nM and 289 nM at human and rat TRPA1 receptors), with analgesic and antiinflammatory effects and is used in scientific research, but has not been developed for medical use. |
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V128005 | AAL-149 | 177258-60-5 | AAL-149 is an FTY720 analog and TRPM7 inhibitor (IC50 = 1.081 μM) with multimodal anti-inflammatory activity and does not target the S1P receptor. |
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V10018 | AC1903 | 831234-13-0 | AC1903 is a selective and specific inhibitor of TRPC5 with podocyte protective properties. |
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V116887 | Acoltremon-d3 | Deuterated aclotetramon-d3 (WS-12-d3) is a deuterated aclotetramon. | |
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V115982 | ADM 12 | 1644134-60-0 | ADM 12 is a highly selective transient receptor potential aniloxetine 1 (TRPA1) channel antagonist. |
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V128387 | AG1529 | 2225980-49-2 | AG1529 is a TRPV1 inhibitor, belonging to the capsaicin class of soft analgesics, with an IC50 value of 0.9-0.93 μM for human TRPV1. |
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V112526 | AM-0883 | AM-0883 is a TRPC6 (transient receptor potential classical receptor 6) agonist (hTRPC6 EC50 = 46 nM). | |
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V6706 | AM-0902 | 1883711-97-4 | AM-0902 is a novel, potent and selective Transient Receptor Potential A1 (TRPA1) antagonist withIC50s of 71 and 131 nM forrTRPA1andhTRPA1, respectively. |
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V3458 | AMG 333 | 1416799-28-4 | AMG 333 is a novel, potent and highly selectiveTRPM8antagonist with anIC50of 13 nMand 20 nM for hTRPM8 and rTRPM8, respectively. |
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V128673 | AMG 7905 TFA | AMG 7905 TFA is a type 1 vanillic acid receptor antagonist (TRPV1) that can induce transient receptor potentials for hypothermia. | |
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V3400 | AMG 9810 | 545395-94-6 | AMG9810 (AMG-9810) is a nove, potent, selective and competitive antagonist of vanilloid receptor 1 (TRPV1) with cancer-promoting effects. |
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V6811 | ASP7663 | 1190217-35-6 | ASP7663 is an selective and orally bioavailable TRPA1 activator, acting by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo. |
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V70123 | BAY-390 | 2741956-55-6 | BAY-390 is a selective, cross-species active, brain-penetrating TRPA1 inhibitor. |
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