TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70158 | Xeniafaraunol A | 161162-29-4 | Xeniafaraunol A (compound 31) is a potent inhibitor of transient receptor potential melastatin 7 (TRPM7). |
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V117238 | ZA10 | ZA10 is a selective TRPM2 channel inhibitor with an IC50 value of 8.1 μM. | |
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V117422 | ZA18 | 2696407-32-4 | ZA18 is a selective TRPM2 channel inhibitor with an IC50 value of 6.2 μM. |
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V147408 | ZQMT-10 | 1791309-86-8 | ZQMT-10 is an orally effective and potent TRPA1 antagonist with a Kd value of 1.04 μM. |
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V147728 | β-Sanshool | 10076-00-3 | β-Shanzhiol is found in Sichuan pepper (Zanthoxylum bungeanum) and has a unique spicy flavor. |
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V30488 | Beta-Eudesmol | 473-15-4 | Beta-Eudesmol has anticancer and anti~inflammatory activities. |
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V16878 | Trovafloxacin mesylate | 147059-75-4 | Trovafloxacinmesylate (CP-99219) is a broad-spectrum quinolone antibiotic thatinhibits DNA supercoiling in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. |
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V4517 | Mavatrep | 956274-94-5 | Mavatrep (formerly known as JNJ-39439335) is a novel, orally bioavailable, potent and selective TRPV1 antagonist (Ki = 6.5 nM) with a potential to manageinflammatory pain. |
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V39083 | Adenosine 5′-diphosphoribose sodium | 68414-18-6 | Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a novel nicotinamide adenine nucleotide (NAD+) metabolite, and is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. |
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V26922 | Ononetin | 487-49-0 | Ononetin, a naturally occurring deoxybenzoinisolated from the Russian traditional medicine plant Ononis spinosa,is a novel and potent TRPM3 (transient receptor potential melastatin 3) channel blocker (IC50=300 nM). |
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V2715 | Capsazepine | 138977-28-3 | Capsazepine is a novel, potent and synthetic antagonist of TRPM8 channels (IC50 = 562 nM) with potential anticancer activity. |
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V17503 | Capsaicin ((E)-Capsaicin) | 404-86-4 | Capsaicin ((E)-Capsaicin),a mixture of Capsaicin and Dihydrocapsaicin, is an active component isolatedd from chili peppers, which are plants belonging to the genus Capsicum, acting as a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells. |
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V32020 | Dihydrocapsaicin | 19408-84-5 | Dihydrocapsaicin is a naturally occuring capsaicin isolated from Capsicum fruit, it acts as a potent and selective TRPV1 agonist, and also increases p-Akt levels. |
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V15471 | Nonivamide | 2444-46-4 | Nonivamide is an agonist with a 4d-EC50 of 5.1 mg/L in static toxicity assays. |
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V6708 | Adarotene (ST1926) | 496868-77-0 | Adarotene (ST-1926),a synthetic, phenolic hydroxyl retinoid with proapoptotic activity,is an atypical retinoid and a promising anti-tumour agent with selective apoptotic activity on the leukaemic blast. |
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