Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V133220 | Daurisoline-d2 | Daurisoline-d2 is a deuterated Daurisoline. | |
|
V133221 | Daurisoline-d5 | Daurisoline-d5 is the deuterated Daurisoline. | |
|
V91743 | Dehydrosoyasaponin I | 117210-14-7 | Dehydrosoyasaponin I (Soyasaponin Be; DHS-I), a triterpene glycoside, is a potent and reversible activator of calcium-activated potassium (maxi-K) channels. |
|
V77091 | Dendrotoxin K TFA | Dentrotoxin K TFA is a Kv1.1 channel blocker. | |
|
V73639 | Dendrotoxin-I (DTX-I) | 107950-33-4 | Dendrotoxin-I is a potent K+ channel blocker that targets the voltage-gated potassium channel subunits KV1.1 and KV1.2. |
|
V100256 | Dendrotoxin-I TFA | Dendritoxin-I (DTX-I) TFA is a potent K+ channel blocker with IC50 of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6. | |
|
V73660 | Dihydroisopimaric acid | 5673-36-9 | Dihydroisopimaric acid activates BK channel alphabeta1 under whole-cell voltage clamping. |
|
V73603 | DPO-1 | 43077-30-1 | DPO-1 is a potent inhibitor of the voltage-gated potassium channel Kv1.5 and a blocker of ultrafast delayed rectifier potassium currents. |
|
V134309 | DPP8/9-IN-2 | 3109603-86-0 | DPP8/9-IN-2 is a DPP8/9 inhibitor with IC50 values of 0.22 nM and 3 nM, and Ki values of 2.9 nM and 6 nM, respectively. |
|
V103448 | E-4031 free base | 113558-89-7 | E-4031 free base is a selective hERG potassium channel blocker used in class III antiarrhythmic studies. |
|
V117600 | E0199 | 931928-13-1 | E0199 is a novel and highly effective KV7/NaV dual-target modulator that activates KV7 potassium channels (including KV7.2/7.3 (EC50 = 12.78 nM), KV7.2 (EC50 = 0.50 μM), and KV7.5 (EC50 = 27.14 nM)) while inhibiting NaV1.7 (IC50 = 0.52 μM), NaV1.8 (IC50 = 0.24 μM), and NaV1.9 (IC50 = 0.16 μM) sodium channels. |
|
V134798 | E0714 | 1359358-36-3 | E0714 is a selective Kv7.2 potassium channel activator that can cross the blood-brain barrier, with EC50 values of 1.90 μM for homotetrameric Kv7.2 channels and 0.021 μM for heterotetrameric Kv7.2/7.3 channels. |
|
V3382 | E4031 diHCl | 113559-13-0 | E-4031 diHCl (E4031 dihydrochloride) is a novel, potent and selective blocker of hERG K+ channels, which is also termed as a class III antiarrhythmic agent. |
|
V84881 | Ebio1 | 339287-36-4 | |
|
V134868 | Ebio2 | Ebio2 is a potent KCNQ2 activator. | |
|
V134869 | Ebio3 | Ebio3 is a selective potassium channel (KCNQ2) inhibitor with an IC50 value of 1.2 nM. | |
|
V135000 | eIF2B activator-1 | 3118633-46-5 | eIF2B activator-1 is an eIF2B activator with a pEC50 value of 7.3. |
|
V114316 | Emakalim | 129729-66-4 | Emakalim is an ATP-dependent potassium channel agonist. |
|
V105016 | ER degrader 10 | 3035311-43-1 | ER degrader 10 (Compound 51) is an oral, selective estrogen receptor (ER) degrader and antagonist with a DC50 of 0.43 nM and an IC50 of 0.56 nM. |
|
V109945 | ERG-IN-4 | 3047672-14-7 | ERG-IN-4 (compound 12) is an orally effective selective ERG inhibitor with an IC50 value of 5.2 μM for hERG. |
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