Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1678 | Glyburide (Glibenclamide) | 10238-21-8 | Glyburide (formerly HB419; HB420;Glibenclamide;Micronase; Diabeta; Maninil; Micronase; Neogluconin) is a selective blocker of vascular ATP-sensitive K+ channels (KATP) that has been approved as an antidiabetic sulfonylurea drug used for the treatment of type 2 diabetes. |
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V1673 | Glimepiride (Glimperide; HOE-490) | 93479-97-1 | Glimepiride (HOE-490; HOE490; Amaryl;Glimepiridum;Amarel; Glimepirida; Roname), a third generation andmedium-to-long actingsulfonylurea compound, is a potent Kir6.2/SUR inhibitor with potential antidiabetic activity. |
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V0229 | Gliclazide (S1702; Diamicron) | 21187-98-4 | Gliclazide (S-1702; trade names Diamicron among others),a sulfonylurea insulin secretagogue,is an approved medication forthe treatment of type 2 diabetes. |
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V4951 | Clofilium tosylate | 92953-10-1 | Clofilium tosylate, the tosylate salt of clofilium, is a novel and potent potassium/K+ channel blocker with the potential to be used as a cardiac depressant and anti-arrhythmic agent. |
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V1681 | Ciclopirox ethanolamine (HOE 296) | 41621-49-2 | Ciclopirox ethanolamine (formerly HOE-296; HOE296; Ciclopirox olamine), the ethanolamine salt ofCiclopirox,is a novel, investigational, synthetic, potent and broad-spectrum antifungal agent working as an iron chelator and used as an antifungal agent for topical dermatologic treatment of superficial mycoses. |
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V1675 | Repaglinide (AG-EE 623ZW) | 135062-02-1 | Repaglinide (AG-EE388 ZW; AG-EE-623 ZW, Prandin, GlucoNorm, Surepost, NovoNorm)is a potent and short-acting potassium channel blocker with antidiabetic activity. |
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V0192 | Tolbutamide (HLS-831) | 64-77-7 | Tolbutamide (also known as HLS 831; trade names: Artosin, Diabetol, Orinase),a sulfonylurea analog,is a potent and selectiveinhibitor of potassium channel used as an oral blood-glucose-lowering/hypoglycemicmedication. |
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V1670 | Dronedarone HCl (SR33589) | 141625-93-6 | Dronedarone HCl (formerly SR-33589;D4689; W3083; D03914; S-7529; RL01735),the hydrochloride salt of dronedarone,is a non-iodinated amiodarone analog approved for the treatment for Atrial fibrillation (AF). |
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V10387 | Doxapram hydrochloride (AHR-619) | 7081-53-0 | Doxapramhydrochloride (AHR619)is a respiratory stimulant that can also inhibit TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
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V41791 | Nifekalant hydrochloride (MS-551) | 130656-51-8 | Nifekalant hydrochloride (MS-551) is an IKr potassium channel blocker belonging to the class III antiarrhythmic agentwith an IC50 of 10 µM. |
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V1672 | Amiodarone HCl (NSC 85442) | 19774-82-4 | Amiodarone HCl(formerly NSC-85442; NSC85442;NSC 85442; Cordarone),the hydrochloride salt of amiodarone, is an antiarrhythmic drugused to treat and prevent an irregular heartbeat. |
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V1679 | Mitiglinide Calcium (KAD-1229) | 145525-41-3 | Mitiglinide Calcium (formerlyKAD-1229; S-21403; KAD1229; S21403;Glufast), the calcium salt ofMitiglinide, is a potassiun channel blocker that has been approved asa blood glucose-lowering drug for the treatment of type 2 diabetes. |
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V12383 | Minoxidil | 38304-91-5 | Minoxidil (U-10858; Loniten; Rogaine)is anantihypertensive agentand vasodilatorthat has also found usefulness in treatment of hair loss andalopecia areatawhenapplied topically. |
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V3523 | Naminidil | 220641-11-2 | Naminidil (BMS 234303-01) is a novel and potentcyanoguanidineKATPopener (ATP-Sensitive Potassium Channel Vasodilator). |
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V29291 | Vernakalant (RSD-1235) | 794466-70-9 | Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. |
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V25309 | Mesoridazine free base | 5588-33-0 | Mesoridazine is a potent phenothiazine dopamine receptor anatagonist that is able to inhibit D2DR and D4DR. |
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V14863 | SKA-31 | 40172-65-4 | SKA-31 is a potassium channel activator. |
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V0198 | Nateglinide (Starlix; A4166) | 105816-04-4 | Nateglinide (formerly A-4166; trade names: Fastic, Starlix), a meglitinide analog,is a potent and orally bioavailableantihyperglycemic medication used for treating type 2 diabetes [non-insulin-dependent diabetes mellitus (NIDDM)]. |
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V3861 | Amifampridine | 54-96-6 | Amifampridine (trade name: Firdapse; pyridine-3,4-diamine, 3,4-diaminopyridine, 3,4-DAP) is an FDA approved drug used predominantly in the treatment of a number of rare muscle diseases such as Lambert-Eaton myasthenic syndrome (LEMS) in adults. |
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