The ion channel known as the calcium channel exhibits selective permeability to calcium ions. Although there are ligand-gated calcium channels as well, it is sometimes referred to as a voltage-dependent calcium channel. Even though the concentration of Na+ outside of cells is 70 times higher than that of Ca2+, voltage-gated calcium (CaV) channels catalyze a rapid, highly selective influx of Ca2+ into cells. A side effect of some calcium channel blockers is that they slow your heart rate, which helps to lower blood pressure, treat angina, and regulate irregular heartbeats.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V29489 | (-)-Praeruptorin A | 73069-25-7 | Praeruptorin A [(9R,10S) isomer] is a naturally occuring di-esterified coumarin derivative extracted from thedried roots of Peucedanum praeruptorumDunn, which is atraditional Chinese medicine used for the treatment of cough with thick sputum and dyspnea. |
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V4180 | (R)-(+)-Bay-K-8644 | 98791-67-4 | R)-(+)-Bay-K-8644, the R-isomer ofBay-K-8644, is a novel and potent acalcium channelinhibitor/blocker that inhibits Ba2+currents (IBa) (IC50=975 nM). |
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V4179 | (S)-(-)-Bay-K-8644 | 98625-26-4 | S)-(-)-Bay-K-8644, the S-enantiomer ofBay-K-8644,is a novel and potent Ca2+ channel activator that activates Ba2+currents (IBa) with an EC50of 32 nM. |
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V2931 | ABT-639 | 1235560-28-7 | ABT-639 is a new potent, peripherally acting, selective T-type Ca2+channel blocker that blocks recombinant human T-type (Cav3.2) Ca2+channels in a voltage-dependent fashion (IC50=2 μM) and attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 μM). |
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V1687 | AMG-517 | 659730-32-2 | AMG 517 (AMG-517; AMG517) is a novel, potent and selective TRPV1 (vanilloid receptor-1) antagonist with potential anti-inflammatory activity. |
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V0650 | Amlodipine (UK-48340; Norvasc) | 88150-42-9 | Amlodipine (formerly UK48340; trade name Norvasc among others), a marketed antihypertensive drug, is a long-acting L-type calcium channel blocker/CCB of the dihydropyridine/DHP class. |
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V0349 | Amlodipine Besylate (Norvasc) | 111470-99-6 | Amlodipine (formerly UK-48340;Norvasc; used as as besylate, mesylate or maleate salts) is a selective and long-acting CCB-calcium channel blocker that belongs to the dihydropyridine (DHP) class. |
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V28956 | Amlodipine maleate | 88150-47-4 | Amlodipine maleate (Amvaz;Norvasc), the maleate salt ofAmlodipine, is anantihypertensive medication of the dihydropyridine (DHP) classused for lowering blood pressure,angina pectoris and preventing chest pain. |
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V11167 | Amlodipine mesylate | 246852-12-0 | Amlodipine mesylate (Amlodis; Amlor, Coroval; Lipinox; Norvasc; Amvaz), the mesylate salt of Amlodipine, is an approved anti-hypertensive drug of the dihydropyridine (DHP) class used for lowering blood pressure. |
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V7612 | Aranidipine | 86780-90-7 | Aranidipine (MPC1304) is a calcium ion (Ca2+) channel antagonist (inhibitor) with potent and long-lasting anti-hypertensive (blood pressure lowering) effects. |
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V2495 | Astragaloside A (Astramembrannin I; Astragalin A) | 83207-58-3 | Astragaloside A (also called Astragaloside IV) is the major pure and active form of saponin isolated from Astragalus membranaceus in Traditional Chinese Medicin, and has been widely used for the treatment of cardiovascular diseases (e. |
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V1688 | Ataluren (PTC124) | 775304-57-9 | Ataluren (formerly known as PTC 124; PTC-124;PTC124; trade name Translarna) is a novel, potent and orally bioavailableCFTR-G542Xnonsense allele inhibitor that has been approved asa medication for the treatment of Duchenne muscular dystrophy. |
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V0563 | Azelnidipine (UR12592, CS-905, CCRIS-8650) | 123524-52-7 | Azelnidipine (also called UR-12592, CS 905,Calblock and CCRIS 8650), a novel dihydropyridine derivative, isa 3rd generation andlong-acting L-type calcium channel blocker, and an antihypertensive drug sold in Japan by Daiichi-Sankyo pharmaceuticals, Inc. |
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V41122 | Azumolene | 64748-79-4 | Azumolene (EU4093 free base), an analog of Dantrolene, is a muscle relaxant. |
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V12289 | Barnidipine HCl | 104757-53-1 | Barnidipine HCl (Mepirodipine; Y 198561; YM-730; YM09730-5) is a novel and potent calcium channel blocker with antihypertensive effects. |
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V4181 | BAYK 8644 (racemate) | 71145-03-4 | BAYK 8644 [(+/-)-Bay K-8644] is a novel and potent L-type Ca2+ channel activator with an EC50 of 17.3 nM. |
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V0885 | Benidipine HCl | 91599-74-5 | Benidipine HCl (formerly SC-278724, KW-3049 HCl; trade namesSular; Coniel) isthe hydrochloride salt form of benidipine which is a DHP/dihydropyridine calcium channel blocker/CCB with anti-hypertensive activity. |
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V12544 | Bepridil HCl hydrate | 68099-86-5 | Bepridil hydrochloridehydrate is a potent calcium channel blocker/antagonist and class IV anti-arrhythmic agent once used to treat angina but is no longer on the market. |
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V1708 | Betamethasone (NSC-39470; SCH-4831) | 378-44-9 | Betamethasone (also called NSC-39470; SCH-4831;NSC39470; SCH4831)is a glucocorticoid steroid and an approved medication with moderateanti-inflammatory and immunosuppressive activities. |
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V1705 | Betamethasone Dipropionate | 5593-20-4 | Betamethasone Dipropionate (Alphatrex; BetaVal; Diprolene;SCH-11460; SCH11460;Diprolene AF; Diprosone; Luxiq; Betamethasone 17,21-dipropionate) is a synthetic glucocorticoid steroid with anti-inflammatory and immunosuppressive activities. |
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