Aquaporins (AQPs) are integral membrane proteins that aid in the movement of water along an osmotic gradient across biological membranes. To date, 13 AQP isoforms (AQP0-AQP12) have been found in rodents and humans. While AQP0-2, 4-6, and 8 are typically thought of as being only water channels, AQP3, 7, 9, and 10 are known as aquaglyceroporins because they are also permeable to glycerol. Within the cell membrane, AQPs typically adopt a tetramer conformation, with each monomer consisting of a single water-permeable aqueous pore. The concentration of the transported molecule affects the passive movement of water and solutes through AQP channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V37574 | AER-271 | 634913-39-6 | AER-271 is a novel and potent aquaporin-4 (AQP4) inhibitor that blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. |
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V34169 | Z433927330 | 1005883-72-6 | Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively. |
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