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Tau Protein

Tau Protein

The role of tau as a microtubule-associated protein in neurons is well established. They play major roles in preserving the stability of microtubules in axons and are widely distributed in central nervous system (CNS) neurons. However, in a variety of neurodegenerative disorders collectively known as tauopathies, aberrant assembly of tau into insoluble aggregates is accompanied by synaptic dysfunction and neural cell death.

Tau Protein related products

Structure Cat No. Product Name CAS No. Product Description
IONIS-MAPTRx sodium V87846 IONIS-MAPTRx sodium IONIS-MAPTRx sodium is the first antisense oligonucleotide (ASO) that lowers Tau.
JG-23 V70069 JG-23 2640819-75-4 JG-23 is a 4-chloromodified analog that promotes t-tau degradation.
JNJ-64326067 V138268 JNJ-64326067 2173357-28-1 JNJ-64326067 is an aggregated tau protein binder with blood-brain barrier permeability and a Ki value of 2.4 nM.
Lithium orotate V138924 Lithium orotate 5266-20-6 Lithium orotate is an orally effective lithium supplement with low binding capacity that can bypass amyloid aggregation in mouse models of Alzheimer's disease (AD).
Lithium salicylate V111116 Lithium salicylate 552-38-5 Lithium salicylate (LiS) is an orally effective lithium salt.
MAO-B-IN-31 V87850 MAO-B-IN-31 MAO-B-IN-31 (Compound 30) is a potent and selective monoamine oxidase B inhibitor with IC50 of 41 nM.
MAO-B-IN-45 V139428 MAO-B-IN-45 3069915-36-9 MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B.
MG-2119 V70066 MG-2119 1065500-40-4 MG-2119 is a potent monomeric tau and α-syn aggregation inhibitor.
Moponetug V119648 Moponetug 3031519-40-8 Moponetug is a humanized IgG1κ antibody that targets MAPT, with a corresponding isotype control being the human IgG1 kappa isotype control.
MRL828 V140407 MRL828 3115333-82-6 MRL828, based on ATTEC technology, combines a Tau pathotropic ligand with a modified guanine moiety to selectively target aggregated Tau protein and clear it via the ALP pathway.
O-GlcNAcase-IN-5 V141822 O-GlcNAcase-IN-5 690215-80-6 O-GlcNAcase-IN-5 is a selective O-GlcNAcase inhibitor.
ONC-841 V141903 ONC-841 ONC-841 is a humanized monoclonal antibody that can cross the blood-brain barrier and targets SIGLEC10.
PNT001 V142895 PNT001 PNT001 is a human IgG1 monoclonal antibody (mAb) that targets cis-phosphorylated Tau protein (cis-pT231 Tau).
QC-01–175 V87848 QC-01–175 2267290-96-8 QC-01-175 is a heterobifunctional molecule that degrades abnormal tau.
RA-PR058 V143846 RA-PR058 RA-PR058 is an orally effective ramarin derivative with blood-brain barrier permeability, exhibiting multi-target regulatory effects and favorable pharmacokinetic properties.
RI-AG03 V106305 RI-AG03 RI-AG03 is an orally active peptide Tau aggregation inhibitor that can penetrate the blood-brain barrier.
RI-AG03 acetate V117407 RI-AG03 acetate RI-AG03 acetate is the acetate form of RI-AG03.
SB1617 V85832 SB1617
SGK1-IN-7 V144827 SGK1-IN-7 3109982-58-0 SGK1-IN-7 is an SGK1 inhibitor that can cross the blood-brain barrier, with an IC50 value of 0.72 μM.
T807 (AV1451) V32942 Flortaucipir (T-807; AV-1451) 1415379-56-4 T807 is a new tau positron emission tomography (PET) tracer.
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