The role of tau as a microtubule-associated protein in neurons is well established. They play major roles in preserving the stability of microtubules in axons and are widely distributed in central nervous system (CNS) neurons. However, in a variety of neurodegenerative disorders collectively known as tauopathies, aberrant assembly of tau into insoluble aggregates is accompanied by synaptic dysfunction and neural cell death.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V119907 | CHIPOpt | CHIPOpt is a peptide that belongs to the ortho-heterogeneous CHIP TPR domain inhibitors, with a Kd value of approximately 16 nM. | |
|
V70094 | CNS-11 | 445218-34-8 | CNS-11 is a compound that breaks down tau fibrils. |
|
V132122 | COX-2/HDAC6-IN-1 | COX-2/HDAC6-IN-1 is a dual COX-2 and HDAC6 inhibitor with an IC50 of 0.12 μM for HDAC6 and 0.66 μM for COX-2. | |
|
V94860 | D-687 | 2276762-06-0 | D-687 is an inhibitor of Tau and Aβ. |
|
V94870 | D-688 | 2276762-07-1 | D-688 is an inhibitor of Tau and Aβ. |
|
V134736 | D-TLKIVWC | 3105302-84-6 | D-TLKIVWC is a tau protein cellulose depolymerizer. |
|
V133347 | DDL-357 | 3077900-08-1 | DDL-357 is a potent secretory cluster protein enhancer. |
|
V133928 | Diranersen | 2304711-06-4 | Diranersen is an antisense oligonucleotide that targets the human MAPT gene to inhibit the production of tau protein. |
|
V120380 | Diranersen scramble control | IONIS-MAPTRx (sodium) is a scrambled version of the IONIS-MAPTRx sodium sequence. | |
|
V133929 | Diranersen sodium | Diranersen sodium is an antisense oligonucleotide that targets the human MAPT gene to inhibit the production of tau protein. | |
|
V109418 | Dopegal | 13023-73-9 | Dopamine is a metabolite of norepinephrine. |
|
V134906 | Edutirsen sodium scrambled negative control | Edutirsen sodium scrambled negative control is a negative control with the sequence of Edutirsen sodium scrambled. | |
|
V106432 | Etalanetug | Etalanetug is an IgG1κ humanized antibody against MAPT. | |
|
V136101 | Florzolotau | 1565797-16-1 | Florzolotau is a positron emission tomography (PET) ligand that can be used to detect Alzheimer's disease (AD) and other tau protein diseases. |
|
V80072 | GSK-3β inhibitor 15 | GSK-3β inhibitor 15 (Compound 54) is a GSK-3β inhibitor (IC50= 3.4 nM). | |
|
V96684 | GSK-3β inhibitor 21 | GSK-3β inhibitor 21 (compound 44) is an ATP-competitive GSK-3β inhibitor (IC50=6.06 μM) with anti-amyloid aggregation and tau phosphorylation inhibitory activities. | |
|
V136972 | GSK-3β/HDAC-IN-2 | GSK-3β/HDAC-IN-2 is a potent inhibitor of GSK-3β (IC50 = 0.04 μM), HDAC2 (IC50 = 1.05 μM, Ki = 0.070 μM), and HDAC6 (IC50 = 1.52 μM, Ki = 0.017 μM). | |
|
V136975 | GSK3β-IN-3 | 301359-45-5 | GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50 = 0.90 μM). |
|
V70088 | hBChE-IN-1 | 1776948-12-9 | hBChE-IN-1 (compound 4) is a quinolyl analogue that is a potent inhibitor of hBChE (IC50=7 nM) and has high selectivity over hAChE. |
|
|
V70074 | IONIS-MAPTRx (BIIB080; ISIS 814907) | 2857842-32-9 | IONIS-MAPTRx (BIIB080) is the first Tau-reducing antisense oligonucleotide (ASO). |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
