A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V117528 | MAO-A/B-IN-5 | MAO-A/B-IN-5 is an orally effective inhibitor of MAO-A (IC50 = 73.88 μM) and MAO-B (IC50 = 91.08 μM). | |
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V70682 | MAO-B-IN-10 | 2376710-36-8 | MAO-B-IN-10 (compound 4f) is a specific, BBB (blood-brain barrier) penetrating MAO-B (monoamine oxidase-B) inhibitor (antagonist) with IC50 of 5.3 μM. |
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V70689 | MAO-B-IN-17 | 2890188-81-3 | MAO-B-IN-17 is a selective monoamine oxidase B (MAO-B) inhibitor (antagonist) with IC50 of 5.08 μM and may be utilized in the study of PD/Parkinson's disease. |
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V79013 | MAO-B-IN-18 | MAO-B-IN-18 is a potent and specific MAO B inhibitor (antagonist) with IC50 of 52 nM and 14 μM for hMAO B and hMAO A respectively. | |
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V70646 | MAO-B-IN-2 | 1253978-24-3 | MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50s of 0.51 and 7.00 μM, respectively. |
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V79879 | MAO-B-IN-20 | MAO-B-IN-20 (Compound C14) is a potent inhibitor of MAO-B with IC50 of 0.037 μM. | |
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V70699 | MAO-B-IN-21 | 2956426-18-7 | MAO-B-IN-21 (compound 10x) is a potent MAO-B inhibitor (antagonist) with anti-oxidant effect and anti-Aβ aggregation activity. |
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V70663 | MAO-B-IN-23 | 2107978-22-1 | MAO-B-IN-23 (Compound 11f) is a reversible and competitive MAO-B inhibitor (IC50= 1.44 μM, Ki= 0.51 μM). |
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V80681 | MAO-B-IN-25 | 2097148-47-3 | MAO-B-IN-25 (compound 92) is a selective MAO-B inhibitor (antagonist) with IC50s of 0.5 nM and 240 nM for MAO-A and MAO-B, respectively. |
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V70656 | MAO-B-IN-27 | 788824-83-9 | MAO-B-IN-27 (Compound 12c) is a monoamine oxidase B (MAO-B) inhibitor. |
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V86217 | MAO-B-IN-28 | 3028096-72-9 | |
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V84587 | MAO-B-IN-29 | 122823-57-8 | |
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V79144 | MAO-B-IN-3 | MAO-B-IN-3 is a reversible and selective MAO-B inhibitor (IC50=96 nM). | |
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V83442 | MAO-B-IN-30 | 82973-15-7 | |
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V139422 | MAO-B-IN-32 | MAO-B-IN-32 is an inhibitor of MAO-B (IC50 = 16 nM). | |
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V100335 | MAO-B-IN-33 | 2286257-25-6 | MAO-B-IN-33 (Compound C3) is a potent, reversible and selective monoamine oxidase-B (MAO-B) inhibitor with IC50 of 0.021 μM and 26.805 μM for MAO-B and MAO-A, respectively. |
|
V94894 | MAO-B-IN-34 | 86710-21-6 | MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase MAO-B. |
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V93722 | MAO-B-IN-36 | MAO-B-IN-36 (Compound A6) is a potent MAO-B inhibitor with IC50 of 13 nM. | |
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V104471 | MAO-B-IN-37 | 894280-02-5 | MAO-B-IN-37 (Compound 37), a derivative of TT01001, is a selective inhibitor of monoamine oxidase B (MAO-B) with IC50 of 270 nM. |
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V105079 | MAO-B-IN-38 | MAO-B-IN-38 (compound 6b) is a reversible competitive MAO-B inhibitor with IC50 values of 0.03 and 21.46 µM for MAO-B and MAO-A, respectively. |
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