A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V138552 | L&M-D-MR | L&M-D-MR is a highly specific fluorescent AND logic probe whose responding groups can recognize leucine aminopeptidase (LAP) and monoamine oxidase (MAO). | |
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V70692 | Ladostigil (TV-3326) | 209394-27-4 | Ladostigil (TV-3326) is an orally bioavailable dual (bifunctional) inhibitor of cholinesterase (cholinesterase) and brain-selective monoamine oxidase (MAO). |
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V70691 | Ladostigil hemitartrate (TV-3326 hemitartrate) | 209394-46-7 | Ladostigil (TV-3326) hemitartrate is an orally bioavailable dual (bifunctional) inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO). |
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V70694 | Ladostigil hydrochloride (TV-3326 hydrochloride) | 209394-18-3 | Ladostigil (TV-3326) HCl is an orally bioavailable dual (bifunctional) inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO). |
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V70695 | Lazabemide hydrochloride (Ro 19-6327 hydrochloride) | 103878-83-7 | Lazabemide HCl (Ro 19-6327 HCl) is a selective and reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM), but has low activity against MAO-A (IC50>100 μM). |
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V70649 | LOX-IN-3 dihydrochloride monohydrate | 2414974-55-1 | LOX-IN-3 diHCl monohydrate (Compound 33) is an orally bioactive lysyl oxidase (LOX) inhibitor for fibrosis, cancer and angiogenesis research. |
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V41859 | LOX-IN-3 dihydrochloride | 2409964-23-2 | LOX-IN-3 (PXS5505; PXS-5505) dihydrochloride is a novel and oral inhibitor of lysyl oxidase (LOX)with potential usefulness for treatment of a variety of disorders, e. |
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V139037 | LOXL2-IN-1 tosylate | LOXL2-IN-1 tosylate is a selective, orally active lysyl oxidase-like 2 (LOXL2) inhibitor with an IC50 of <300 nM. | |
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V110795 | LOXL2/sGC modulator-1 | LOXL2/sGC modulator-1 (compound 11k) is a LOXL2 inhibitor (IC₅₀ = 0.13 μM) and sGC activator. | |
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V110799 | LOXL2/sGC modulator-2 | LOXL2/sGC modulator-2 (compound 9k) is a selective, orally effective dual-target modulator that simultaneously regulates lysyl oxidase-like protein 2 (LOXL2) and soluble guanylate cyclase (sGC). | |
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V139082 | LSD1-IN-10 | 1235864-15-9 | LSD1-IN-10 is an LSD1/MAO inhibitor with an IC50 value of 5 nM for LSD1, 16 μM for MAO-A, and 7.4 μM for MAO-B. |
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V80144 | Lysyl hydroxylase 2-IN-1 | Lysyl hydroxylase 2-IN-1 (compound 12) is a selective lysyl hydroxylase 2 (LH2) inhibitor (antagonist) with IC50 of approximately 300 nM. | |
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V80029 | Lysyl hydroxylase 2-IN-2 | Lysyl hydroxylase 2-IN-2 (compound 13) is a potent inhibitor of Lysyl hydroxylase 2 (LH2) with IC50 of approximately 500 nM. | |
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V139418 | MAO Probe 1 | 1386860-79-2 | MAO Probe 1 is a reactive two-photon fluorescent probe that can cross the blood-brain barrier to detect the activity of monoamine oxidases (MAO-A/MAO-B), with Km values of 70 μM (MAO-A) and 75 μM (MAO-B), respectively. |
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V86089 | MAO-A inhibitor 1 | 119229-96-8 | |
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V83416 | MAO-A inhibitor 2 | ||
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V139419 | MAO-A inhibitor 3 | 35924-44-8 | MAO-A inhibitor 3 is an MAO-A inhibitor with an IC50 >100 μM. |
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V139420 | MAO-A-IN-2 | 1627618-37-4 | MAO-A-IN-2 is a selective monoamine oxidase A (MAO-A) inhibitor with an IC50 value of 0.4 μM. |
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V70688 | MAO-A/5-HT2AR-IN-1 | 2769156-00-3 | MAO-A/5-HT2AR-IN-1 (compound I14) is a potent dual (bifunctional) inhibitor of MAO-A and 5-HT2AR with IC 50 of 0.004 and 0.014 μM, respectively. |
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V80133 | MAO-A/B-IN-2 | MAO-A/B-IN-2 (Compound 30) is an MAO-A/B inhibitor (antagonist) with IC50s of 17.8 and 15.8 μM for MAO-A and MAO-B, respectively. |
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