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Monoamine Oxidase

Monoamine Oxidase

A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.

Monoamine Oxidase related products

Structure Cat No. Product Name CAS No. Product Description
Harmane-d (Harmane-d1) V76938 Harmane-d (Harmane-d1) Harmane-d is the deuterium labelled form of Harmane.
Harmane-d2 (Harmane-d2) V79700 Harmane-d2 (Harmane-d2) Harmane-d2 is the deuterium labelled form of Harmane.
hMAO-A-IN-1 V85743 hMAO-A-IN-1 1039315-88-2
hMAO-B-IN-10 V104236 hMAO-B-IN-10 hMAO-B-IN-10 (Compound 7) is an inhibitor of MAO-A/B with IC50 of 424.1 nM and 177.9 nM, respectively.
hMAO-B-IN-12 V117567 hMAO-B-IN-12 3087062-50-5 hMAO-B-IN-12 (compound 6E) is a highly selective inhibitor of human monoamine oxidase B (hMAO-B) (IC50 = 17.7 nM).
hMAO-B-IN-5 V70654 hMAO-B-IN-5 358343-63-2 hMAO-B-IN-5(B15) is a specific and reversible inhibitor of human monoamine oxidase hMAO-B with IC50 of 0.12 μM.
hMAO-B-IN-6 V85813 hMAO-B-IN-6 2764830-43-3
hMAO-B-IN-7 V85425 hMAO-B-IN-7 2955577-14-5
hMAO-B/MB-COMT-IN-1 V70661 hMAO-B/MB-COMT-IN-1 254974-70-4 hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: hMAO-B is 2.5 μM, MB-COMT is 3.84 μM).
Homopterocarpin ((-)-Homopterocarpin; 3,9-Dimethoxypterocarpan) V70679 Homopterocarpin ((-)-Homopterocarpin; 3,9-Dimethoxypterocarpan) 606-91-7 Homopterocarpin is an isoflavone that can be extracted from Pterocarpus erinaceus.
Hydroxylamine (50% w/w in water) V119919 Hydroxylamine (50% w/w in water) 7803-49-8 Hydroxylamine is a selective monoamine oxidase (MAO) inhibitor used to inhibit platelet aggregation.
Hydroxylamine-d3 hydrochloride (hydroxylamine hydrochloride-d3; hydroxylamine hydrochloride-d3) V70658 Hydroxylamine-d3 hydrochloride (hydroxylamine hydrochloride-d3; hydroxylamine hydrochloride-d3) 15588-23-5 Hydroxylamine-d3 ( HCl) is the deuterated form of Hydroxyamine HCl.
IHC3 V80226 IHC3 IHC3 is a competitive and reversible inhibitor of MAO-B (IC50= 1.672 μM).
Illudinine V137878 Illudinine 18500-63-5 Illudinine is a sesquiterpene alkaloid and a monoamine oxidase B (MAO-B) inhibitor with an IC50 value of 18.3 μM.
Insecticidal agent 32 V137988 Insecticidal agent 32 25939-05-3 Insecticidal agent 32 is an insecticide and monoamine oxidase inhibitor.
Iproclozide V112496 Iproclozide 3544-35-2 Sinderesin is an irreversible selective monoamine oxidase inhibitor with antidepressant effects.
J147 V22802 J147 1146963-51-0 J147 is a potent neuroprotective and neurotrophic compound.
J147 V84211 J147 1807913-16-1
Kynuramine dihydrobromide V70650 Kynuramine dihydrobromide 304-47-2 Kynuramine diHBr is an endogenous amine and a fluorescent substrate for plasma amine oxidase.
Kynuramine dihydrochloride V70642 Kynuramine dihydrochloride 36681-58-0 Kynuramine is an endogenous amine and a fluorescent substrate and probe for plasma amine oxidase.
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