A plasma membrane protein called dopamine transporter (DAT) mediates extracellular dopamine (DA) reuptake and regulates the spatiotemporal dynamics of dopaminergic neurotransmission. DATs are essential for stopping dopaminergic signaling and preserving a dopamine pool that can be released. DATs actively shuttle released transmitter molecules back across the plasma membrane into dopaminergic neurons, where they can be sequestered for later use or enzymatic catabolism. This helps to modulate the concentration of extraneuronal dopamine.
DAT is the primary target of a number of psychostimulants, nootropics, antidepressants, and some recreational drugs, such as the notoriously addictive stimulant cocaine. Cocaine-like inhibitors and amphetamine-like substrates are the two categories into which DAT ligands have traditionally been divided. A number of signaling systems, including PKC, control DAT.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71787 | (R)-Phenylpiracetam (MRZ 9547) | 949925-07-9 | (R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (antagonist) with Ki and IC50 of 14.8 μM and 65.5 μM respectively. |
|
V71786 | 13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol) | 178765-49-6 | 13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol) is extracted from Psoralea corylifolia and is an analog of Bakuchiol. |
|
V71788 | 3-CPMT (Tropine 4-chlorobenzhydryl ether hydrochloride) | 14008-79-8 | 3-CPMT (Tropine 4-chlorobenzyl ether HCl) is a potent dopamine uptake inhibitor. |
|
V71785 | 5,7-Dimethoxyluteolin | 90363-40-9 | 5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin analogue, is a dopamine transporter (DAT) activator with EC50 of 3.417 μM. |
|
V71784 | AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) | 202646-03-5 | AHN 1-055 HCl is a dopamine uptake inhibitor (antagonist) with IC50 of 71 nM. |
|
V70652 | CAD031 | 2071209-49-7 | CAD031 is an analogue of the AD/Alzheimer's disease targeting agent J147 with neuro-protection and memory-enhancing properties. |
|
V29672 | Dasotraline | 675126-05-3 | Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 of 4, 6, and 11 nM, respectively. |
|
V70004 | Desipramine-d3 (desipramine hydrochloride-d3; desipramine hydrochloride-d3) | 65100-49-4 | Desipramine-d3 is deuterium labelled Desipramine. |
|
V70006 | Desipramine-d4 (desipramine hydrochloride-d4; desipramine hydrochloride-d4) | 61361-34-0 | Desipramine-d4 is the deuterium labelled form of Desipramine. |
|
V2046 | GBR 12935 | 76778-22-8 | GBR-12935 is a novel, potent and selective dopamine reuptake inhibitor. |
|
V2045 | GBR 12935 HCl | 67469-81-2 | GBR-12935 is a novel, potent and selective dopamine reuptake inhibitor and a piperazine derivative. |
|
V27943 | Vanoxerine dihydrochloride | 67469-78-7 | Vanoxerine dihydrochloride (GBR-12909; I-893) is a novel, potent, competitive and highly selective dopamine ruptake inhibitor (Ki=1 nM) with the potential for the treatment of atrial fibrillation. |
|
V71783 | Z1078601926 | 1493256-85-1 | Z1078601926 is an allosteric inhibitor of human dopamine transporter (hDAT). |
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