As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V106274 | RI-OR2-TAT | 1430219-69-4 | RI-OR2-TAT is a brain-penetrating amyloid-β oligomerization inhibitor generated by adding the HIV protein transduction domain TAT to RI-OR2. |
|
V71442 | Sabirnetug | 2747959-38-0 | Sabirnetug is a humanized IgG2κ antibody targeting the Amyloid-β A4 precursor protein. |
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V119596 | SAR228810 | SAR228810 is a humanized IgG4 monoclonal antibody inhibitor that targets amyloid β (Aβ). Its KD value for fibrillary Aβ is 0.43 nM, which is higher than that for monomeric Aβ. | |
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V71411 | Scrambled β-amyloid (1-40) | 1678415-68-3 | Scrambled β-amyloid (1-40) is a biologically active peptide. |
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V101347 | SEN 304 | SEN 304 is an Aβ aggregation inhibitor. | |
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V144866 | SHR-1707 | SHR-1707 is a humanized anti-Aβ IgG1 monoclonal antibody. | |
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V145023 | SLAFVDVLN | SLAFVDVLN is a molecular peptide and a BACE-1 inhibitor with a Ki value of 94 nM. | |
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V14996 | SNU-0039 (DWK-133) | 1018946-38-7 | SNU-0039(DWK-133) is an orally bioavailable inhibitor of β-amyloid protein aggregation with the potential to be used as an anti-Alzheimers agent. |
|
V99661 | SOD1 (147-153) human | 2760733-01-3 | SOD1 (147-153) human is a peptide fragment of Cu/Zn superoxide dismutase (SOD1) with a high propensity to form amyloid fibrils. |
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V79665 | SQ-3 | SQ-3 is a quinoline analogue with moderate selectivity for α-syn aggregates (Ki=39.3 nM) and over β-amyloid (Aβ) aggregates with Ki of 39.3 nM and 230 nM respectively. | |
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V145243 | Squoxin | 1096-84-0 | Squoxin is an anti-amyloid drug that specifically binds to Aβ1-42, preventing Aβ aggregation and fibrillation. |
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V103699 | tau Protein/α-synuclein-IN-2 | Tau Protein/α-synuclein-IN-2 (Compound 14T) is a tau and α-syn inhibitor that penetrates the blood-brain barrier. | |
|
V81539 | tau/Aβ40 aggregation-IN-1 | 2973377-10-3 | tau/Aβ40 aggregation-IN-1 (Compound 20) is an inhibitor (blocker/antagonist) of tau and Aβ40 aggregation with IC50 of 1.8 μM and 1.3 μM respectively. |
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V115317 | TDI-2760 | 956128-08-8 | TDI-2760 is an Aβ aggregation inhibitor with an IC50 value of 1.67 μM. |
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V101632 | TFEB activator 2 | 3027414-04-3 | TFEB activator 2 (compound 37) possesses TFEB activation and lysosomal biogenesis abilities. |
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V87777 | TFEB activator 3 | 3027413-48-2 | TFEB activator 3 (compound 45) exhibits TFEB activation and lysosomal biogenesis abilities. |
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V115475 | TI-16 | 659739-64-7 | TI-16 is a polypeptide that targets β-amyloid protein (Aβ). |
|
V71361 | Tramiprosate-d6 (Homotaurine-d6; 3-Amino-1-propanesulfonic acid-d6) | 1131576-06-1 | Tramiprosate-d6 is the deuterated form of Tramiprosate. |
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V71400 | YIAD-0205 | 2446054-34-6 | YIAD-0205 is an orally bioactive Aβ(1?42) aggregation inhibitor. |
|
V147294 | Zamubafusp alfa | 2937458-25-6 | Zamubafusp alfa is an immunoglobulin-peptide fusion protein composed of humanized IgG1 and panamyloid protein reactive peptide p5R. |
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