As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V141055 | N-Caffeoyldopamine | N-Caffeoyldopamine is a β-amyloid aggregation inhibitor. | |
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V71367 | OAB-14 | 2140911-49-3 | OAB-14, a Bexarotene analogue, improves AD/Alzheimer's disease-related pathology and cognitive impairment by increasing beta-amyloid clearance in APP/PS1 mice. |
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V71428 | p-HTAA | 1175142-38-7 | p-HTAA is a pentameric hydrothiopheneacetic acid. |
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V98931 | Pep63 | 1781242-18-9 | Pep63 is a neuroprotective peptide (VFQVRARTVA). |
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V142506 | PF-04382923 | PF-04382923 is a humanized IgG2Δa monoclonal antibody. | |
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V71380 | PHF6 | 329897-62-3 | PHF6 (VQIVYK) is a self-assembly sequence that initiates aggregation of full-length tau protein and maps to the third microtubule-binding repeat region of tau protein. |
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V87773 | PHF6 TFA | PHF6 (VQIVYK) TFA is a self-assembly sequence that initiates aggregation of full-length tau and is mapped to the third microtubule-binding repeat region of tau. | |
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V119948 | PMN310 | PMN310 is a monoclonal antibody that targets β-amyloid oligomers (AβO). | |
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V87772 | QM-FN-SO3 ammonium | QM-FN-SO3 ammonium is a near-infrared (NIR) aggregation-induced emission (AIE) active probe that can penetrate the brain barrier. | |
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V85737 | QP5020 | 3027434-06-3 | |
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V85705 | QP5038 | 3031429-88-3 | QP5038 is a QPCTL inhibitor with IC50 of 3.8 nM. |
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V71386 | QR-0217 | 1027786-12-4 | QR-0217 is a potent Aβ1-40 aggregation inhibitor (antagonist) with IC50 of 7.5 µM. |
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V143660 | QSH peptide | 470459-60-0 | QSH peptide is a peptide that specifically binds to Aβ1-42 and is used to synthesize siRNA delivery complexes. |
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V115118 | R-MA-SLM | R-MA-SLM is a ratiometric H₂O₂ responsive fluorescent probe that can target Aβ and cross the blood-brain barrier. | |
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V76567 | RAGE antagonist peptide TFA | RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. | |
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V70008 | RAGE/SERT-IN-1 | 2766739-35-7 | RAGE/SERT-IN-1 is a potent and orally bioactive inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT) with IC50s of 8.26 μM and 31.09 nM, respectively. |
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V71415 | RAGE antagonist peptide | 1092460-91-7 | RAGE antagonist peptide is an advanced glycation end product (RAGE) antagonist. |
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V71374 | Remternetug (LY3372993) | 2571940-41-3 | Remternetug is a humanized immunoglobulin G1-kappa, anti-APP (amyloid beta A4 precursor protein) Aβ42 N3pGlu peptide monoclonal antibody (mAb). |
|
V99699 | RERMS | 148914-08-3 | RERMS are bioactive peptides generated from the active regions of amyloid-β and A4 protein precursors that promote fibroblast growth and can be used in the study of neurodegenerative diseases. |
|
V106273 | RI-OR2 | 1219627-58-3 | RI-OR2 is a retroviral peptide that inhibits amyloid-β (Aβ) oligomerization. |
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