As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78469 | Biotin-β-Amyloid (1-42), human TFA (Biotin-amyloid β-peptide (1-42) (human) TFA) | Biotin-β-Amyloid (1-42), human TFA (Biotin-Amyloid β-Peptide (1-42) (human) TFA) is biotin-labeled β-Amyloid (1-42), human TFA. | |
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V78470 | Biotin-β-Amyloid (17-40) | Biotin-β-Amyloid (17-40) is an N-terminally tagged biotinylated amyloid β-Amyloid (17-40) peptide. | |
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V86132 | Buntanetap L-Tartrate ((+)-Phenserine L-Tartrate; ANVS401 L-Tartrate) | 865795-23-9 | |
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V87779 | Carnosine conjugated hyalyronate | Carnosine conjugated hyalyronate is a hyaluronic acid derivative functionalized with the dipeptide carnosine (Car), which has the ability to resist Aβ amyloid aggregation. | |
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V88215 | Cbz-Gly-Pro-Ala-O-cinnamyl | Cbz-Gly-Pro-Ala-O-cinnamyl (compound 25) is a small peptide targeting BACE-1 and AChE with IC50 values of 0.02 μM and 1 μM, respectively. | |
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V77153 | Chemerin-9 (149-157) (TFA) | Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1). | |
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V78803 | Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40); Citrullinated Aβ40) | Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40)) is a modified form of β-Amyloid (1-40) that is citrullinated at the Arg5 site. | |
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V78804 | Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42); Citrullinated Aβ42) | Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42)) is a modified form of β-Amyloid (1-42) that is citrullinated at the Arg5 site. | |
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V71365 | Cl-NQTrp | 185351-23-9 | Cl-NQTrp significantly disrupts preformed fibrillar aggregates of tau-derived PHF6 (VQIVYK) peptide and full-length tau protein. |
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V71432 | Coumarinic acid | 495-79-4 | Coumarinic acid is a brain-penetrating inhibitor of AChE and β-amyloid. |
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V18783 | CRANAD-2 | 1193447-34-5 | CRANAD-2 is adifluoroboron-based curcumin acting as anear-infrared (NIR) Aβ plaque-specific fluorescent probe for in vivo detection of amyloid-beta deposits. |
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V87774 | Cy5-β-Amyloid (42-1), human | Cy5-β-Amyloid (42-1), human is β-Amyloid (42-1, human) peptide labeled with Cy5 fluorescence (λex= 633 nm, λem= 670 nm). | |
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V71377 | D-KLVFFA | 342877-55-8 | D-KLVFFA is an inhibitor (blocker/antagonist) of Amyloid-β assembly with IC50 of 2.6 μM. |
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V80071 | DDC 2′,3′-O-disulfate | DDC 2′,3′-O-disulfate (compound 4) prevents fibrillation and oligomerization of Aβ42. | |
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V71362 | Direct Red 80 (Sirius Red; Sirius Red) | 2610-10-8 | Direct Red 80 (Sirius Red) is a polyazo dye primarily used in staining methods for collagen and amyloid. |
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V101326 | DN5355 | 937012-09-4 | DN5355 is a bifunctional small molecule compound targeting amyloid β protein (Aβ) and hyperphosphorylated tau protein. It can inhibit the aggregation of Aβ and tau proteins and dissociate the formed Aβ and tau protein fibers. It can be used in the study of Alzheimer's disease. |
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V11347 | Emrusolmin (Anle138b) | 882697-00-9 | Anle138b is a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. |
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V1315 | EUK 134 | 81065-76-1 | EUK 134 (EUK-134; EUK134), a synthetic and cell permeable superoxide dismutase (SOD)/catalase mimetic, is a novel antioxidant compound that exhibits potent antioxidant activities. |
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V79435 | FITC-β-Ala-β-Amyloid (25-35) | FITC-β-Ala-β-Amyloid (25-35) is a fluorescent product labeled by FITC and may be utilized in the research of AD/Alzheimer's disease. | |
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V79436 | FITC-β-Amyloid (25-35) | FITC-β-Amyloid (25-35) is FITC labeled β-Amyloid (25-35). |
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