As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V15809 | Deferoxamine mesylate | 138-14-7 | Deferoxamine is an novel iron chelator that is able to bind to free iron in a stable complex, it is also a bacterial siderophore produced by the Actinobacteria Streptomyces pilosus. |
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V33327 | (2-Hydroxypropyl)-β-cyclodextrin USP grade | 128446-35-5 | 2-Hydroxypropyl)-β-cyclodextrin is a cyclodextrin oligosaccharide that has been widely used drug delivery vehicle to improve the aqueous solubility,stability and bioavailability of chemical compounds. |
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V2021 | Hematoxylin (Haematoxylin) | 517-28-2 | Hematoxylin (also known as Hydroxybrazilin; Natural Black 1) is a natural compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology. |
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V4468 | Bavachinin (BVC; 7-O-Methylbavachin; Bavachinin A) | 19879-30-2 | Bavachinin(BVC; 7-O-Methylbavachin; Bavachinin A) is a naturally occuring compound isolated from the fruit of the traditional Chinese herb Fructus Psoraleae (FP). |
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V31301 | Hoechst 34580 (HOE 34580) | 23555-00-2 | Hoechst 34580 is a marking dye from the Hoechst range. |
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V2883 | Azeliragon (TTP488; PF-04494700) | 603148-36-3 | Azeliragon (also known as TTP488 and PF-04494700) is a potent and orally bioavailable RAGE (Receptor for Advanced Glycation End products) inhibitor that has the potential for the treatment ofmild-to-moderate Alzheimers disease and cerebral amyloid angiopathy. |
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V20400 | Edonerpic maleate | 519187-97-4 | Edonerpic, formerly known as T-817, is a neuroprotectant. |
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