G protein-coupled receptors (GPCRs) known as free fatty acid receptors (FFARs) are activated by free fatty acids (FFAs). FFAR1/GPR40, FFAR2/GPR43, FFAR3/GPR41, and FFAR4/GPR120 are the four FFARs that have been thoroughly characterized. FFA2 and FFA3 are activated by short chain FFAs, primarily acetate, butyrate, and propionate; FFARs are classified according to the chain length of the FFA ligands that activate each FFAR. FFA1 and GPR120 are activated by medium- or long-chain FFAs, whereas GPR84 is activated by medium-chain FFAs.Each FFAR can therefore function as an FFA sensor with selectivity for a specific FFA carbon chain length derived from food or food-derived metabolites. According to research, FFARs play a variety of physiological roles, including promoting the release of the hormones insulin and incretin, adipocyte differentiation, anti-inflammatory effects, neuronal responses, and taste preferences. It is possible to think of these FFAR physiological functions as regulating immune and energy homeostasis. As a result, therapeutic strategies for the treatment of metabolic disorders like type 2 diabetes and metabolic syndrome have focused on FFARs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V109530 | Tricosanoic acid-d3 | 2732915-45-4 | Tricosanoic acid-d3 is a deuterated derivative of tricosanoic acid. |
|
V109554 | Tricosanoic acid-d45 | Tricosanoic acid-d45 is a deuterated derivative of tricosanoic acid. | |
|
V51362 | TUG-499 | 1206629-08-4 | TUG-499 is a cross-coupling related adapter 1 (FFAR1 or GPR40) (free fatty acid receptor) agonist/activator with pEC50 of 7.39. |
|
V3445 | TUG-770 | 1402601-82-4 | TUG-770 (TUG770) is a novel, highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40) with EC50 of 6 nM for hFFA1. |
|
V16933 | TUG-891 | 1374516-07-0 | TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which displays both potential opportunity and possible challenges to therapeutic agonism. |
|
V147187 | Ximeninic acid | 557-58-4 | Ximeninic acid is a fatty acid. |
|
V7595 | Pinocembrin racemate (DL0108) | 68745-38-0 | Pinocembrin (DL-0108), the racemate of Pinocembrin, is a potent androgen receptor ligand with the potential for the treatment of acute stroke. |
|
V5236 | Vincamine | 1617-90-9 | Vincamine is a peripheral vasodilator, that increases blood flow to the brain. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
