CCR

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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CCR

Chemokine receptors, or CCRs, are cytokine receptors that can be found on the surface of some cells and interact with specific chemokines. Mammals have 19 different chemokine receptors that have been identified. They are all members of a large protein family known as G protein-coupled receptors because they each have a 7-transmembrane (7TM) structure and couple to G-protein for signal transduction inside of a cell. Chemokine receptors cause an increase in intracellular calcium (Ca2+) ions after interacting with their particular chemokine ligands (calcium signaling).Cell responses result from this, and one of them is the beginning of the chemotaxis process, which directs the cell to the desired area of the organism. The four different subfamilies of chemokines that chemokine receptors bind are grouped into four families: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors. Some chemokine receptors act as entry points for HIV, while others support inflammatory conditions and cancer.

CCR related products

Cat No.	Product Name	CAS No.	Product Description
V146927	Velaprumig	2988741-17-7	Velaprumig is a monoclonal antibody that targets human CD99, CCL25, and anti-human Aβ (Aβ-47F).
V93219	Vicriviroc malate	541503-81-5	Vicriviroc (SCH 417690) malate is an oral CCR5 antagonist with IC50 > 10 nM, and also inhibits MIP-1α and RANTES ligand-induced intracellular calcium release with IC50 values of 0.91 nM and 16 nM, respectively.
V146985	Viscumneoside V	119016-92-1	Viscumneoside V is a plant-derived anti-inflammatory agent found in Viscum album var.
V147000	VLST-002		VLST-002 is a humanized antibody expressed in CHO cells that targets CCL5/RANTES.
V115374	YJC-10592	1226894-87-6	YJC-10592 is an orally effective CCR-2 antagonist.
V86569	YM-344031	671204-98-1	YM-344031 is an orally active CCR3 antagonist.
V74750	ZK 756326	874911-96-3	ZK756326 is a non-peptide chemokine receptor agonist (activator) that targets the CC chemokine receptor CCR8.
V28513	ZK-756326 dihydrochloride	1780259-94-0	ZK756326 diHCl is a non-peptide chemokine receptor agonist (activator) that works on the CC chemokine receptor CCR8.
V147367	ZL-1218		ZL-1218 is a selective humanized IgG1 antibody that targets CCR8.
V147368	ZL-1218 (FUT8-KO)		ZL-1218 (FUT8-KO) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out.
V2026	Bindarit (AF2838)	130641-38-2	Bindarit (also known as AF-2838; AF 2838) is a potent and selective inhibitor of monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8 with anti-inflammatory activity.
V3651	Vercirnon	698394-73-9	Vercirnon (formerly also known as CCX282-B and GSK1605786) is a novel, potent, orally bioavailable, selective antagonist of CCR9 with an IC50 of 10 nM, used in the research of inflammatory bowel diseases.
V51095	Vercirnon sodium (CCX282-B; GSK-1605786A)	886214-18-2	CCR9 antagonist
V3644	Aplaviroc	461443-59-4	Aplaviroc (formerly known as AK-602; GW-873140; ONO-4128; GW873140A; GSK-873140), a SDP (spirodiketopiperazine) derivative, is a CCR5 entry inhibitor with the potential treatment of HIV infection.
V3645	Aplaviroc HCl	461023-63-2	Aplaviroc HCl (GW873140A; ONO-4128; AK-602; GSK 873140) is the hydrochloride salt of Aplaviroc which is a SDP (spirodiketopiperazine) derivative, and a CCR5 entry inhibitor with anti-HIV activity.
V1810	Maraviroc (UK427857)	376348-65-1	Maraviroc (also known as UK-427857)is a potent, selective and non-competitive CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively.
V51114	Maraviroc-d6	1033699-22-7	Maraviroc-d6 is the deuterium labelled form of Maraviroc.
V4675	Vicriviroc maleate (SCH-417690 maleate）	599179-03-0	Vicriviroc maleate (formerly known as SCH 417690; SCH-D), the maleate salt of vicriviroc, is a novel, potent, selective, orally bioavailable and CNS penetrant antagonist ofCCR5entry inhibitor of HIV-1with aKiof 2.5 nM, and also inhibits HIV-1 in PBMC cells, withIC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570).