Chemokine receptors, or CCRs, are cytokine receptors that can be found on the surface of some cells and interact with specific chemokines. Mammals have 19 different chemokine receptors that have been identified. They are all members of a large protein family known as G protein-coupled receptors because they each have a 7-transmembrane (7TM) structure and couple to G-protein for signal transduction inside of a cell. Chemokine receptors cause an increase in intracellular calcium (Ca2+) ions after interacting with their particular chemokine ligands (calcium signaling).Cell responses result from this, and one of them is the beginning of the chemotaxis process, which directs the cell to the desired area of the organism. The four different subfamilies of chemokines that chemokine receptors bind are grouped into four families: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors. Some chemokine receptors act as entry points for HIV, while others support inflammatory conditions and cancer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V86574 | INCB9471 | 869769-98-2 | INCB9471 is a potent, selective and orally active CCR5 antagonist. |
|
V74751 | IPG7236 | 2756350-91-9 | IPG7236 is a selective CCR8 antagonist. |
|
V106396 | Lanerkitug | Lanerkitug is a human IgG1λ2 antibody directed against CCR8. | |
|
V138633 | Lanerkitug (FUT8-KO) | Lanerkitug (FUT8-KO) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. | |
|
V51093 | Lazucirnon (ALK-4290; AKST-4290) | 1251528-23-0 | CCR3 inhibitor |
|
V138950 | LMD-584 | 521979-66-8 | LMD-584 is an agonist of CCR8. |
|
V118838 | LMD-902 | 521979-59-9 | LMD-902 is an analogue of LMD-009 and is also a CCR8 agonist with an EC50 value of 15 nM. |
|
V86572 | LT166 | LT166 is a fluorescent ligand for CC chemokine receptor 1 (CCR1) with a KD of 1.90 μM. | |
|
V110491 | LUF7996 | 3104736-80-0 | LUF7996 is a PROTAC degrader targeting CCR2 with a half-lethal concentration (DC50) of 2.6 μM. |
|
V111356 | LUF8100 | 2954281-30-0 | LUF8100 is a CCR2/CCR5 dual-target antagonist with a pKi value of 5.23 for CCR2 and a pKi value of 4.97 for CCR5. |
|
V51103 | Met-RANTES (human) | 1883816-50-9 | Met-RANTES (human) is part of a family of CCR5 antagonists. |
|
V96937 | Met-RANTES (human) (acetate) | Met-RANTES (human) acetate is the acetate salt of Met-RANTES (human). | |
|
V139970 | Minokitug | 3061919-24-9 | Minokitug is a humanized monoclonal antibody that targets the CCR2 protein. |
|
V4298 | MK0812 | 624733-88-6 | MK-0812 (MK0812) is a novel, potent and selective small molecule CCR2 antagonist with potential anti-Inflammatory and immunomodulatory activity. |
|
V4297 | MK0812 Succinate | 851916-42-2 | MK0812 Succinate (MK-0812) is a novel, potent and selective small molecule CCR2 antagonist with anti-Inflammatory and immunomodulatory activity. |
|
V113770 | mNOX-E36 | mNOX-E36 is a mouse-specific analogue of NOX-E36, which is an anti-CCL-2 L-RNA aptamer that can bind to and neutralize the mouse chemokine CCL-2. | |
|
V106439 | Nebokitug | Nebokitug is an IgG1κ human antibody directed against CCL24. | |
|
V51091 | PF-07054894 | 2413693-96-4 | PF-07054894 is a potent CCR6 antagonist. |
|
V3261 | PF-4136309 (INCB-8761) | 1341224-83-6 | PF-4136309 (formerly known as INCB8761) is a novel, potent, selective, and orally bioavailable small molecule CCR2 antagonist with IC50 values of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2, respectively. |
|
V102742 | PF-4178903 | 1310796-72-5 | PF-4178903 (INCB10820) is an orally active dual CCR2 and CCR5 antagonist with IC50 values of 3 nM and 5.3 nM, respectively. |
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