Chemokine receptors, or CCRs, are cytokine receptors that can be found on the surface of some cells and interact with specific chemokines. Mammals have 19 different chemokine receptors that have been identified. They are all members of a large protein family known as G protein-coupled receptors because they each have a 7-transmembrane (7TM) structure and couple to G-protein for signal transduction inside of a cell. Chemokine receptors cause an increase in intracellular calcium (Ca2+) ions after interacting with their particular chemokine ligands (calcium signaling).Cell responses result from this, and one of them is the beginning of the chemotaxis process, which directs the cell to the desired area of the organism. The four different subfamilies of chemokines that chemokine receptors bind are grouped into four families: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors. Some chemokine receptors act as entry points for HIV, while others support inflammatory conditions and cancer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V106391 | Denikitug | Denikitug is an IgG1κ chimeric antibody targeting CCR8. | |
|
V106427 | Denrakibart | Denrakibart is an IgG2κ human antibody directed against CCL17. | |
|
V116290 | Dicytidine 5′-triphosphate | 149297-81-4 | Dicytidine 5′-triphosphate (Cp3C) is a cytosine-containing dinucleotide polyphosphate. |
|
V110479 | Dicytidine 5′-triphosphate trisodium | 1629163-10-5 | Dicytidine 5′-triphosphate sodium (Cp3C) is a cytosine-containing dinucleotide polyphosphate. |
|
V134276 | DOTA-ECL1i | 2850189-48-7 | DOTA-ECL1i is a conjugate of the CCR2 inhibitor ECL1i and DOTA. |
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V115976 | DPC-168 | 275810-55-4 | DPC-168 is an orally effective CCR3 antagonist (IC50 = 41 nM). |
|
V115420 | Dpep24 | 3114880-03-1 | Dpep24 is a highly selective, high-affinity cyclic D-type sulfate peptide inhibitor. |
|
V112090 | ECL1i | 1417312-35-6 | ECL1i is an allosteric selective CCR2 inhibitor. |
|
V108992 | ECL1i TFA | ECL1i TFA is an allosteric selective CCR2 inhibitor. | |
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V113694 | Emapticap pegol scramble negative control | Emapticap pegol scramble negative control, an oligonucleotide aptamer, is a negative control for Emapticap pegol. | |
|
V135136 | Enzelkitug | 2999644-88-9 | Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody that targets human CC motif chemokine receptor 8 (CCR8). |
|
V135135 | Enzelkitug (FUT8-KO) | Enzelkitug (FUT8-KO) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. | |
|
V136115 | Flt-3L-Ig (hum/hum) | Flt-3L-Ig (hum/hum) is a Flt3 ligand. | |
|
V136959 | GSK-3050002 | GSK-3050002 is a humanized antibody expressed in CHO cells that targets CCL20. | |
|
V3603 | GSK2239633A | 1240516-71-5 | GSK2239633A (GSK-2239633A), a 4-aminoindazole sulfonamide, is a novel and potent antagonist of human CC-chemokine receptor 4 (CCR4) with anti-inflammatory activity. |
|
V119851 | HGS004 | HGS004 is a humanized IgG4 monoclonal antibody inhibitor that targets CCR5. | |
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V112291 | Histamine glutarimide | 1464897-15-1 | Histamine glutarimide (XC8) is an orally effective anti-asthma medication. |
|
V86573 | IDOR-1117-2520 | 2737274-49-4 | IDOR-1117-2520 is a potent and selective CCR6 antagonist. |
|
V4079 | INCB3344 | 1262238-11-8 | INCB3344 (INCB-3344) is a novel, potent, selective,orally bioavailable small molecule antagonist of the CCR2 receptor with anti-inflammatory activity. |
|
V76893 | INCB3344 R-isomer | INCB3344 R-isomer is the R-isomer of INCB3344. |
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