Chemokine receptors, or CCRs, are cytokine receptors that can be found on the surface of some cells and interact with specific chemokines. Mammals have 19 different chemokine receptors that have been identified. They are all members of a large protein family known as G protein-coupled receptors because they each have a 7-transmembrane (7TM) structure and couple to G-protein for signal transduction inside of a cell. Chemokine receptors cause an increase in intracellular calcium (Ca2+) ions after interacting with their particular chemokine ligands (calcium signaling).Cell responses result from this, and one of them is the beginning of the chemotaxis process, which directs the cell to the desired area of the organism. The four different subfamilies of chemokines that chemokine receptors bind are grouped into four families: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors. Some chemokine receptors act as entry points for HIV, while others support inflammatory conditions and cancer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V117105 | CCR5 modulator-1 | 960296-78-0 | CCR5 regulator-1 (compound 26) is a CCR5 regulator. |
|
V131209 | CCR5-IN-1 | CCR5-IN-1 is a selective allosteric CCR5 inhibitor with an IC50 of 1.09 μM. | |
|
V131208 | CCR5/CXCR3-IN-1 | 680203-04-7 | CCR5/CXCR3-IN-1 is a CXCR3 and CCR5 inhibitor. |
|
V131210 | CCR6 antagonist 2 | CCR6 antagonist 2 is an antagonist of CCR6 with a Ki value of 1.1 nM. | |
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V113423 | CCR6 antagonist 3 | CCR6 antagonist 3 (compound OXM2) is a potent and selective allosteric antagonist of CC chemokine receptor 6 (CCR6) (IC50 = 166 nM). | |
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V113411 | CCR6 antagonist 4 | CCR6 antagonist 4 (compound OXM1) is a potent and selective allosteric antagonist of CC chemokine receptor 6 (CCR6) (IC50 = 158 nM). | |
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V51092 | CCR6 inhibitor 1 | 2437547-04-9 | CCR6 Inhibitor 1 is a potent and potent example of CCR6 with IC50s of 0.45 and 6 nM for monkey and human CCR6, respectively, which is a close match for human CCR1 (IC50, >30000 nM) and CCR7 (IC50), 9400 nM). |
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V104306 | CCR8 agonist 1 | CCR8 agonist 1 (Compound 2) is a CCR8 agonist that can be used to study autoimmune diseases. | |
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V4831 | CCR8 antagonist 1 | 723304-76-5 | CCR8 antagonist 1 (compound 15) is a potent human CCR8 antagonist (inhibitor) with Ki of 1.6 nM. |
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V86576 | CCR8 antagonist 3 | 912463-57-1 | CCR8 antagonist 3 (compound 2) is a CCR8 antagonist with IC50 of 0.062 µM. |
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V131211 | CCR9 ligand-Linker Conjugate 1 | 2906191-39-5 | CCR9 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate containing a CCR9 ligand and a PROTAC linker, which recruits E3 ligases. |
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V110453 | CCR9 modulator-1 | 1111300-51-6 | CCR9 Modulator-1 (Example 16) is a CCR9 modulator. |
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V3746 | Cenicriviroc | 497223-25-3 | Cenicriviroc (formerly known as TAK-652 or TBR-652) is a novel, orally bioactive, and dual antagonist of CCR2/CCR5, it also inhibits both HIV-1 and HIV-2, and has the potential for the treatment of HIV infection. |
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V3747 | Cenicriviroc Mesylate | 497223-28-6 | Cenicriviroc Mesylate (formerly known as TAK-652 Mesylate or TBR-652 Mesylate) is a novel, orally bioactive, and dual antagonist of CCR2/CCR5, it also inhibits both HIV-1 and HIV-2, and has the potential for the treatment of HIV infection. |
|
V84687 | cis-J-113863 | 202796-41-6 | |
|
V51110 | CKLF1-C19 | 960358-79-6 | CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). |
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V131972 | CMKLR1 antagonist 2 | CMKLR1 antagonist 2 is a fully competitive chemokine/chemokine-like receptor 1 (CMKLR1) antagonist with an IC50 of 37 μM. | |
|
V74753 | CMPD167 (MRK-1) | 313994-79-5 | CMPD167 (MRK-1) is an orally bioactive CCR5 inhibitor (antagonist) with potent anti-viral effect in vitro. |
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V132134 | CP-865569 | 478833-25-9 | CP-865569 is a CCR1 antagonist. |
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V132581 | CXCR2/CCR7 antagonist-1 | 473728-04-0 | CXCR2/CCR7 antagonist-1 is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 and 0.0014 μM, respectively. |
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