Chemokine receptors, or CCRs, are cytokine receptors that can be found on the surface of some cells and interact with specific chemokines. Mammals have 19 different chemokine receptors that have been identified. They are all members of a large protein family known as G protein-coupled receptors because they each have a 7-transmembrane (7TM) structure and couple to G-protein for signal transduction inside of a cell. Chemokine receptors cause an increase in intracellular calcium (Ca2+) ions after interacting with their particular chemokine ligands (calcium signaling).Cell responses result from this, and one of them is the beginning of the chemotaxis process, which directs the cell to the desired area of the organism. The four different subfamilies of chemokines that chemokine receptors bind are grouped into four families: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors. Some chemokine receptors act as entry points for HIV, while others support inflammatory conditions and cancer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74751 | IPG7236 | 2756350-91-9 | IPG7236 is a selective CCR8 antagonist. |
|
V106396 | Lanerkitug | Lanerkitug is a human IgG1λ2 antibody directed against CCR8. | |
|
V51093 | Lazucirnon (ALK-4290; AKST-4290) | 1251528-23-0 | CCR3 inhibitor |
|
V86572 | LT166 | LT166 is a fluorescent ligand for CC chemokine receptor 1 (CCR1) with a KD of 1.90 μM. | |
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V51103 | Met-RANTES (human) | 1883816-50-9 | Met-RANTES (human) is part of a family of CCR5 antagonists. |
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V96937 | Met-RANTES (human) (acetate) | Met-RANTES (human) acetate is the acetate salt of Met-RANTES (human). | |
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V4298 | MK0812 | 624733-88-6 | MK-0812 (MK0812) is a novel, potent and selective small molecule CCR2 antagonist with potential anti-Inflammatory and immunomodulatory activity. |
|
V4297 | MK0812 Succinate | 851916-42-2 | MK0812 Succinate (MK-0812) is a novel, potent and selective small molecule CCR2 antagonist with anti-Inflammatory and immunomodulatory activity. |
|
V106439 | Nebokitug | Nebokitug is an IgG1κ human antibody directed against CCL24. | |
|
V51091 | PF-07054894 | 2413693-96-4 | PF-07054894 is a potent CCR6 antagonist. |
|
V3261 | PF-4136309 (INCB-8761) | 1341224-83-6 | PF-4136309 (formerly known as INCB8761) is a novel, potent, selective, and orally bioavailable small molecule CCR2 antagonist with IC50 values of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2, respectively. |
|
V102742 | PF-4178903 | 1310796-72-5 | PF-4178903 (INCB10820) is an orally active dual CCR2 and CCR5 antagonist with IC50 values of 3 nM and 5.3 nM, respectively. |
|
V5046 | RS 102895 HCl | 1173022-16-6 | RS-102895 HCl (RS 102895), the hydrochloride salt of RS102895, is a novel and potent chemokine receptor CCR2 antagonist anticancer activity. |
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V3754 | SB297006 | 58816-69-6 | SB297006 (SB-297006) is an antagonist of CCR3 (Chemokine receptor, IC50 = 39 nM) with anticancer activity. |
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V51094 | SB-328437 | 247580-43-4 | SB-328437 is a potent, selective, non-peptide CCR3 antagonist (inhibitor) with IC50 of 4.5 nM. |
|
V74755 | SB-649701 | 935262-95-6 | SB-649701 is a potent human CCR8 antagonist (inhibitor) with pIC50 of 7.7. |
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V86575 | SQA1 | 1255915-27-5 | SQA1, a squaramide (SQA) derivative, is a CCR6 antagonist with a Kd of 250 nM. |
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V4592 | TAK-779 | 229005-80-5 | TAK-779 (TAK779) is a novel, potent and selective nonpeptide antagonist of CCR5 [C-C chemokine receptor type 5 (CCR5) receptor] and CXCR3 with potential anticancer, immunomodulatory and antiinflammatory activities. |
|
V51089 | Tivumecirnon (FLX-475) | 2174938-78-2 | Tivumecirnon (FLX475) is a potent CCR4 antagonist tumor agent that blocks the regulation of anti-immune responses that effectively interferes with T cells and has anti-tumor activity. |
|
V84354 | trans-J-113863 | 202796-42-7 |
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