Chemokine receptors, or CCRs, are cytokine receptors that can be found on the surface of some cells and interact with specific chemokines. Mammals have 19 different chemokine receptors that have been identified. They are all members of a large protein family known as G protein-coupled receptors because they each have a 7-transmembrane (7TM) structure and couple to G-protein for signal transduction inside of a cell. Chemokine receptors cause an increase in intracellular calcium (Ca2+) ions after interacting with their particular chemokine ligands (calcium signaling).Cell responses result from this, and one of them is the beginning of the chemotaxis process, which directs the cell to the desired area of the organism. The four different subfamilies of chemokines that chemokine receptors bind are grouped into four families: CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors, and XC chemokine receptors. Some chemokine receptors act as entry points for HIV, while others support inflammatory conditions and cancer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V131007 | CAP-100 | CAP-100 is a monoclonal antibody that targets CCR7. | |
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V86570 | CB-0821 | 81430-62-8 | CB-0821 is a high-affinity CCR5 inhibitor with a Ki of 0.04 nM. |
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V131201 | CCL17-IN-1 | 3104330-39-1 | CCL17-IN-1 is a CCL17 secretion inhibitor with an EC50 of 0.2 nM. |
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V131202 | CCL17-IN-2 | 3104330-35-7 | CCL17-IN-2 is a CCL17 secretion inhibitor with an EC50 of 0.3 nM. |
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V86571 | CCR1 antagonist 12 | 921208-19-7 | CCR1 antagonist 12 (Compound 12) is a CCR1 antagonist with IC50 of 3 nM for human CCR1. |
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V131205 | CCR1 antagonist 13 | 868408-20-2 | CCR1 antagonist 13 is a selective small molecule antagonist of CCR1. |
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V51116 | CCR1 antagonist 6 | 2436773-01-0 | CCR1 antagonist 6 (compound 16q) is an antagonist of CCR1 with IC50 of 3 nM. |
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V51115 | CCR1 antagonist 7 | 2446154-74-9 | CCR1 antagonist 7 (compound 16r) is an antagonist of CCR1 with IC50 of 4 nM. |
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V131206 | CCR2 antagonist 6 | 1421063-89-9 | CCR2 antagonist 6 is a CCR2 antagonist (CCR2 Kb value is 0.215 μM, hCCR2B Kb value is 0.174 μM). |
|
V110482 | CCR2 ligand-1 | 1350765-28-4 | CCR2 ligand-1 is a ligand for CCR2 that, when combined with linker PIN1 degrader-3 and E3 ligase ligand thalidomide 4-fluoride, can be used to synthesize LUF7996. |
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V131207 | CCR2-IN-1 | 3088041-47-5 | CCR2-IN-1 is a G protein-coupled receptor CCR2 inhibitor. |
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V105561 | CCR2-RA | 512177-31-0 | CCR2-RA is an allosteric antagonist of chemokine (CC motif) receptor 2 (CCR 2) with potential applications in cancer research. |
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V119324 | CCR3 antagonist 2 | 606128-24-9 | CCR3 antagonist 2 (Example 66) is a CCR3 antagonist that can be used to study inflammatory or allergic diseases, particularly inflammatory or obstructive respiratory diseases. |
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V51111 | CCR4 antagonist 3-1 | 1957-01-3 | CCR4 Antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist (inhibitor) with IC50 of 1.7 μM for [125I]TARC (thymic and activation-regulated chemokine). |
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V84814 | CCR4 antagonist 4 | 668980-17-4 | |
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V51098 | CCR4-IN-38 (CCR4-351) | 2174938-70-4 | CCR4 antagonist |
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V51099 | CCR4-IN-38 (CCR4-351) HCl | 2174938-71-5 | CCR4 antagonist |
|
V51113 | CCR5 antagonist 2 | 1800570-93-7 | CCR5 Antagonist 2 (Compound 25) is a CCR5 antagonist (inhibitor) with IC50 of 8.34 nM. |
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V51112 | CCR5 antagonist 3 | 1800570-92-6 | CCR5 Antagonist 3 (Compound 26) is a CCR5 antagonist (inhibitor) with IC50 of 15.90 nM. |
|
V115230 | CCR5 antagonist 4 | 872879-86-2 | CCR5 antagonist 4 is an orally effective CCR5 antagonist. |
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