By making blood vessels tighten, the angiotensin-converting enzyme (ACE) indirectly raises blood pressure. Angiotensin I is changed by ACE into angiotensin II, which tightens the blood vessels. The renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body, is made up of ACE, angiotensin I, and angiotensin II. Cells in the endothelium (inner layer) of blood vessels secrete ACE in the lungs and kidneys.It serves two main purposes: In a substrate concentration-dependent manner, ACE catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Bradykinin, a potent vasodilator, and other vasoactive peptides are broken down by ACE. In order to treat conditions like high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus, ACE inhibition is a goal. By inhibiting ACE (using ACE inhibitors), angiotensin II production and bradykinin metabolism are reduced, which causes a systematic dilation of the arteries and veins and a reduction in arterial blood pressure.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73004 | Imidapril-d3 hydrochloride (Imidapril d3 hydrochloride) | 1356017-30-5 | Imidapril-d3 ( HCl) is the deuterium labelled form of Imidapril HCl. |
|
V117159 | IRW | 159718-10-2 | IRW is an orally bioactive tripeptide extracted from egg white that has angiotensin-converting enzyme (ACE) inhibitory activity. |
|
V73014 | Isocrenatoside | 221895-09-6 | Isocrenatoside (compound 6) is a cyclic octapeptide and an inhibitor (blocker/antagonist) of angiotensin-converting enzyme (ACE). |
|
V73013 | Isomartynoside | 94410-22-7 | Isomartynoside is a potent angiotensin-converting enzyme (ACE) inhibitor (antagonist) with IC50 of 505.9 µM. |
|
V72990 | L-Isoleucyl-L-arginine | 55715-01-0 | L-Isoleucyl-L-arginine is a dipeptide formed from L-isoleucine and L-arginine residues. |
![Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine](http://www.invivochem.com/upload/1124/V73010.png)
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V73010 | Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine | 198284-23-0 | Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is a 4-amino acid (AA) antihypertensive peptide. |
|
V73000 | Lyciumin A | 125708-06-7 | Lyciumin A is a cyclic octapeptide with inhibitory effect against proteases, renin, and angiotensin-converting enzyme. |
|
V72994 | Mca-Ala-Pro-Lys(Dnp)-OH | 305336-82-7 | Mca-Ala-Pro-Lys(Dnp)-OH is a specific ACE2 quenching fluorescent substrate that may be utilized to detect urinary, heart and lung ACE2 activity. |
|
V25708 | MLN-4760 | 305335-31-3 | MLN-4760 is a novel, potent and selective human angiotensin-converting (ACE2) inhibitor with IC50of 0.44 nM and with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA;IC50, 27 μM). |
|
V94512 | Moveltipril calcium | 85921-53-5 | Movipril calcium (MC-838 calcium) is an oral angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. |
|
V140904 | N-Acetyl-Ser-dAsp-Lys-Pro acetate | N-Acetyl-Ser-dAsp-Lys-Pro acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). | |
|
V140905 | N-Acetyl-Ser-dAsp-Lys-Pro TFA | N-Acetyl-Ser-dAsp-Lys-Pro TFA is an endogenous tetrapeptide secreted by the bone marrow and is a specific substrate for the N-terminal site of ACE. | |
|
V111181 | NAVPITPTLNR | 123432-25-7 | NAVPITPTLNR is a casein-derived peptide that belongs to the class of angiotensin I converting enzyme (ACE) inhibitors. |
|
V84879 | Oleacein | 149183-75-5 | |
|
V73002 | Ovalbumin (154-159) | 1370698-94-4 | Ovalbumin (154-159) is a fragment of ovalbumin. |
|
V73003 | Ovotransferrin (328-332) | 1226776-54-0 | Ovotransferrin (328-332) has a protective effect on blood pressure by inhibiting Angiotensin-Converting Enzyme (ACE), with IC50 of 20μM. |
|
V73007 | p-Hydroxyhippuryl-His-Leu | 77697-23-5 | p-Hydroxyhippuryl-His-Leu is a bioactive peptide substrate of ACE (angiotensin-converting enzyme). |
|
V105630 | Quinapril | 85441-61-8 | Quinapril is an oral, nonpeptide and nonthiol angiotensin-converting enzyme (ACE) inhibitor. |
|
V87316 | Quinaprilat hydrochloride | 82586-58-1 | Quinaprilat hydrochloride is an orally active non-thiol angiotensin converting enzyme (ACE) inhibitor and the active metabolite of Quinapril. |
|
V73019 | Quinaprilat-d5 (quinapril-d5) | 1279034-23-9 | Quinaprilat-d5 is a deuterium labelled form of Quinaprilat. |
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