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ACE

ACE

By making blood vessels tighten, the angiotensin-converting enzyme (ACE) indirectly raises blood pressure. Angiotensin I is changed by ACE into angiotensin II, which tightens the blood vessels. The renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body, is made up of ACE, angiotensin I, and angiotensin II. Cells in the endothelium (inner layer) of blood vessels secrete ACE in the lungs and kidneys.It serves two main purposes: In a substrate concentration-dependent manner, ACE catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Bradykinin, a potent vasodilator, and other vasoactive peptides are broken down by ACE. In order to treat conditions like high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus, ACE inhibition is a goal. By inhibiting ACE (using ACE inhibitors), angiotensin II production and bradykinin metabolism are reduced, which causes a systematic dilation of the arteries and veins and a reduction in arterial blood pressure.

ACE related products

Structure Cat No. Product Name CAS No. Product Description
Cilazapril-d5 trifluoroacetate V120066 Cilazapril-d5 trifluoroacetate Cilapril-d5 (Ro 31-2848-d5) trifluoroacetate is a deuterated derivative of cilapril.
Cilazaprilat V87317 Cilazaprilat 90139-06-3 Cilazaprilat (Ro 31-3113) is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 0.7 nM for rat enzyme) and an active metabolite of Cilazapril.
CV 5975 V132570 CV 5975 100277-62-1 CV 5975 is an orally effective competitive inhibitor of angiotensin-converting enzyme (ACE), with a rabbit lung ACE IC50 of 3.1 nM and a Ki value of 2.6 nM.
Delapril-d3 hydrochloride (delapril hydrochloride d3 (hydrochloride)) V73006 Delapril-d3 hydrochloride (delapril hydrochloride d3 (hydrochloride)) 2714473-25-1 Delapril-d3 ( HCl) is the deuterated form of Delapril HCl.
Deserpidine hydrochloride V94258 Deserpidine hydrochloride 6033-69-8 Harmonyl hydrochloride is an antihypertensive compound that competitively inhibits the activity of angiotensin-converting enzyme (ACE).
DX600 V72992 DX600 478188-26-0 DX600 is a selective ACE2-specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE.
Enalaprilat-d5 (Enalaprilat D5; MK-422 d5) V72997 Enalaprilat-d5 (Enalaprilat D5; MK-422 d5) 349554-00-3 Enalaprilat-d5 is the deuterium labelled form of Enalaprilat.
Epicaptopril V100430 Epicaptopril 63250-36-2 Ecaptopril (SQ 14534) is a derivative of captopril.
FA-Phe-Phe V73005 FA-Phe-Phe 83661-95-4 FA-Phe-Phe is a furanoyl acryloyl (fa)-amino acid (AA) analogue that targets angiotensin-converting enzyme (ACE).
FPL 66564 V136336 FPL 66564 140369-78-4 FPL 66564 is a short-acting angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 5.7 nM against rabbit ACE.
Fructose-phenylalanine V136359 Fructose-phenylalanine 31105-03-0 Fructose-phenylalanine is a non-competitive angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.19 mM) with antioxidant activity.
Ganoderic acid K V73016 Ganoderic acid K 104700-95-0 Ganoderic acid K is a potent ACE (angiotensin-converting enzyme) inhibitor.
H-Ile-Pro-Pro-OH hydrochloride V72993 H-Ile-Pro-Pro-OH hydrochloride 1208862-61-6 H-Ile-Pro-Pro-OH HCl is a milk-derived tripeptide that can inhibit ACE (angiotensin-converting enzyme) with IC50 of 5 μM.
H-Lys-Trp-OH V73011 H-Lys-Trp-OH 50674-18-5 H-Lys-Trp-OH (KW) is an ACE inhibitory peptide with IC50 of 7.8 μM.
H-Pro-Phe-OH V73017 H-Pro-Phe-OH 13589-02-1 H-Pro-Phe-OH is a proline- and phenylalanine-containing dipeptide that serves as a substrate for prolinase.
H-Trp-Phe-OH V73009 H-Trp-Phe-OH 6686-02-8 H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe).
H-Tyr-Lys-OH V73015 H-Tyr-Lys-OH 54925-88-1 H-Tyr-Lys-OH is a dipeptide that could be utilized as a biomarker for AJH-1.
HD5 TFA V137168 HD5 TFA HD5 TFA is an innate immune effector peptide and also a SARS-CoV inhibitor.
HOE-288 V116033 HOE-288 93231-79-9 HOE-288 is an orally effective angiotensin-converting enzyme (ACE) inhibitor.
Idrapril V114411 Idrapril 127420-24-0 Idapril is an angiotensin-converting enzyme inhibitor.
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