Dynamins are large superfamily GTPase proteins that are involved in various cellular processes including budding of transport vesicles, division of organelles, cytokinesis, and pathogen resistance. Eukaryotic cells use dynamins to scissor (cleave the vesicle from the parent membrane) developing vesicles from parent membranes. Dynamins sever and release coated vesicles by directly interacting with the lipid bilayer at the necks of clathrin-coated pits. While dynamin-related proteins (DRPs) lack one or more of these domains or have additional domains, dynamins have five domains, including the GTPase domain, middle domain, PH domain, GTPase effector domain (GED), and proline rich domain (PRD).Several different cellular processes, such as cytokinesis and membrane fission in plant cells (Arabidopsis thalianaDRP proteins), pathogen resistance, vacuolar fission in yeast (Saccharomyces cerevisiae Vps1), and interferon-induced antiviral protection (fish Mx proteins) are all regulated by dynamins and DRPs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V102977 | MB-0223 | 2247732-89-2 | MB-0223 is a potent and selective partial inhibitor of the dynein-related GTPase Drp1 (IC50=1.3 μM), which is more selective than other dynein family members Opa1 and dynein-1 (IC50>100 μM). |
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V111718 | N,N-Dimethyldodecylamine | 112-18-5 | N,N-Dimethyldodecylamine is a dynein I inhibitor. |
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V110991 | Opitor-0 | Opitor-0 is a potent and selective inhibitor of guanosine triphosphatase (GTPase) of optic atrophy protein 1 (OPA1), a mitochondrial motility disorder protein, with an IC50 value of 3 μM. | |
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V88807 | P110 | 1411976-18-5 | P110 is a peptide inhibitor of the Drp1-Fis1 interaction that reduces pathological functions in many neurodegeneration, ischemia, and sepsis models without blocking the physiological function of Drp1. |
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V88809 | Pyrimidyn 7 | 1440126-94-2 | Pyrimidyn 7 is a dynamin I/II inhibitor with IC50 values of 1.1 μM and 1.8 μM, respectively. |
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V101151 | Rhodady C10 | 1367579-04-1 | Rhodady C10 (Compound C10) is a dynamin I GTPase inhibitor. |
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V88808 | TAT-P110 | TAT-P110 is a peptide inhibitor that inhibits the Drp1-Fis1 interaction and reduces pathological changes in multiple neurodegenerative disease, ischemia, and sepsis models without impeding the physiological function of Drp1. | |
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V34758 | Trimethyloctadecylammonium bromide | 1120-02-1 | Trimethyloctadecylammonium bromide is a dynamin inhibitor (antagonist) with IC50 of 1.9 μM. |
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V1590 | Dynasore | 304448-55-3 | Dynasore is a cell-permeable, reversible and non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2 (IC50 = 15 μM) with cardioprotective effects. |
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V1591 | Mdivi-1 (Mitochondrial division inhibitor 1) | 338967-87-6 | Mdivi-1 (Mitochondrial Division Inhibitor 1; Mdivi 1; Mdivi1) is a potent selective and cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with the potential for treating stroke, myocardial infarction, and neurodegenerative disease. |
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