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PARP

PARP

PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).

PARP related products

Structure Cat No. Product Name CAS No. Product Description
PARP1 degrader 1 V110790 PARP1 degrader 1 PARP1 degrader 1 (compound 2c) is a relatively effective PARP1 HyT degrader (the intracellular DC50 of PARP-1 is 618 nM).
PARP1-IN-15 V80290 PARP1-IN-15 PARP1-IN-15 (Compound 6) is a PARP1 inhibitor.
PARP1-IN-16 V81047 PARP1-IN-16 PARP1-IN-16 (compound 12a) is a potent PARP1 inhibitor (antagonist) with IC50 of 1.89 nM.
PARP1-IN-17 V79059 PARP1-IN-17 PARP1-IN-17 is a PARP-1 inhibitor (PARP-1 IC50 = 19.24 nM, PARP-2 IC50 = 32.58 nM) and can cause apoptosis.
PARP1-IN-18 V85166 PARP1-IN-18 2958609-64-6
PARP1-IN-19 V84889 PARP1-IN-19 2756337-27-4
PARP1-IN-20 V88726 PARP1-IN-20 2659357-95-4 PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1 with IC50 of 4.62 nM and has similar low PARP trapping effect compared to Veliparib, IC50 (MDA-MB-436) >100 μM.
PARP1-IN-21 V88734 PARP1-IN-21 2855979-51-8 PARP1-IN-21 (example 16) is a potent inhibitor of PARP1 with IC50 of < 10 nM.
PARP1-IN-22 V88731 PARP1-IN-22 3033649-17-8 PARP1-IN-22 (compound 15) is a potent inhibitor of PARP1 with IC50 of < 10 nM.
PARP1-IN-28 V99611 PARP1-IN-28 2855059-11-7 PARP1-IN-28 (Compound 1) is an inhibitor of PARP1.
PARP1-IN-29 V96683 PARP1-IN-29 1567375-93-2 PARP1-IN-29 is an oral PARP-1 inhibitor with IC50 of 6.3 nM.
PARP1-IN-30 V96674 PARP1-IN-30 908803-38-3 PARP1-IN-30 (compound 3) is a specific and potent PARP1 inhibitor with cytotoxicity.
PARP1-IN-33 V104017 PARP1-IN-33 2640677-68-3 PARP1-IN-33 (Example 6) is a PARP1 inhibitor (IC50: 0.41 nM).
PARP1-IN-35 V104555 PARP1-IN-35 PARP1-IN-35 (compound T26) is a selective, orally active, blood-brain permeable PARP1 inhibitor with IC50 values of 0.2 and 122 nM for PARP1 and PARP2, respectively.
PARP1-IN-42 V119614 PARP1-IN-42 3066444-12-7 PARP1-IN-42 (Example 43 cis-a) is a PARP1 inhibitor with an IC50 <10 nM.
PARP1-IN-43 V119366 PARP1-IN-43 3066798-40-8 PARP1-IN-43 (compound 5350) is a PARP1 inhibitor that can cross the blood-brain barrier (BBB) with an IC50 value of 5 nM.
PARP1-IN-44 V117577 PARP1-IN-44 PARP1-IN-44 is an olaparib derivative, an orally effective PARP1 inhibitor (IC50 = 0.6 nM), which also inhibits PARP2 (IC50 = 1.0 nM) and PARP7 (IC50 = 7.5 nM).
PARP1-IN-45 V117740 PARP1-IN-45 PARP1-IN-45 (compound 15) is a PARP1 inhibitor with an IC50 of 17 nM.
PARP1-IN-46 V117590 PARP1-IN-46 2505146-00-7 PARP1-IN-46 is a potent PARP-1 inhibitor with an IC50 value of 2.4 nM.
PARP1-IN-47 V116529 PARP1-IN-47 3053592-61-0 PARP1-IN-47 (compound 35) is a highly selective PARP1 inhibitor (IC50 <100 nM).
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