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PARP

PARP

PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).

PARP related products

Structure Cat No. Product Name CAS No. Product Description
PARP1-IN-6 V51282 PARP1-IN-6 1654735-36-0 PARP1-IN-6 is a tubulin/PARP-1 dual (bifunctional) inhibitor (antagonist) with IC50s of 0.94 and 0.48 μM respectively.
PARP1-IN-7 V51280 PARP1-IN-7 2084112-75-2 PARP1-IN-7 is an inhibitor (blocker/antagonist) of poly(ADP-ribose) polymerase-1 (PARP1) and serves as an anti-cancer compound.
PARP1/2-IN-3 V88729 PARP1/2-IN-3 3032451-58-1 PARP1/2-IN-3 (Compound 29) is an orally active inhibitor of PARP 1 and PARP 2 with IC50 of 0.2235 nM and <0.001 nM, respectively.
PARP1/2-IN-4 V104421 PARP1/2-IN-4 2093102-22-6 PARP1/2-IN-4 (Compound 3) is a PARP1/2 inhibitor.
PARP10-IN-2 V51275 PARP10-IN-2 1042780-52-8 PARP10-IN-2 is a novel mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10.
PARP10-IN-3 V51274 PARP10-IN-3 2225800-19-9 PARP10-IN-3 is a novel mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10.
PARP10/15-IN-1 V75513 PARP10/15-IN-1 2892065-01-7 PARP10/15-IN-1 (compound 8l) is a potent dual (bifunctional) inhibitor of PARP10 and PARP15 with IC50s of 160 nM and 370 nM, respectively.
PARP7-IN-12 V51278 PARP7-IN-12 2819700-92-8 PARP7-IN-12 is a novel and selective inhibitor of PARP7 with an IC50 value of 7.836 nM. In cancer research, PARP7-IN-12 may be useful.
PARP7-IN-14 V51279 PARP7-IN-14 PARP7-IN-14 is a novel and selective inhibitor of PARP7.
PARP7-IN-15 V75510 PARP7-IN-15 2819998-97-3 PARP7-IN-15 (Compound 18) is a PARP7 inhibitor (antagonist) with IC50 of 0.56 nM and anti-tumor activity.
PARP7-IN-16 V75509 PARP7-IN-16 2435657-10-4 PARP7-IN-16 is a specific and orally bioactive PARP-1/2/7 inhibitor (antagonist) with IC50s of 0.94, 0.87 and 0.21 nM respectively.
PARP7-IN-16 free base V97173 PARP7-IN-16 free base 2136325-05-6 PARP7-IN-16 free base is the free form of PARP7-IN-16.
PARP7-IN-17 V85796 PARP7-IN-17 3024030-10-9
PARP7-IN-18 V84185 PARP7-IN-18 2819999-00-1
PARP7-IN-19 V88730 PARP7-IN-19 PARP7-IN-19 (compound 5a) is an inhibitor of PARP7 (IC50 ≤10nM).
PARP7-IN-21 V88737 PARP7-IN-21 3034666-02-6 PARP7-IN-21 (compound 128) is a potent inhibitor of PARP7 with IC50 of < 10 nM.
PARP7-IN-22 V88722 PARP7-IN-22 PARP7-IN-22 (XLY-1) is a PARP7 inhibitor with an IC50 of 0.6 nM.
PARP7-probe-1 V51273 PARP7-probe-1 2379390-76-6 PARP7-probe-1 is a chemiluminescent labeled PARP7 probe. PARP7-probe-1 is an active site-binding biotinylated probe for PARP7. For studying PARP7 function, PARP7-probe-1 can be utilized.
PARPYD V84735 PARPYD 2561483-27-8
PJ34 V30825 PJ34 344458-19-1 PJ34 is a potent and specific PARPl/2 inhibitor (antagonist) with IC50s of 110 nM and 86 nM respectively.
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