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PARP

PARP

PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).

PARP related products

Structure Cat No. Product Name CAS No. Product Description
G244-LM V53252 G244-LM 1563007-08-8 G244-LM is a potent and specific tankyrase 1/2 inhibitor that can suppress Wnt signaling.
GeA-69 V21541 GeA-69 2143475-98-1 GeA-69 (GeA69) is a novel, potent and selective allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2, with a Kd of 2.1 µM.
HYDAMTIQ V75781 HYDAMTIQ 1201832-32-7 HYDAMTIQ is a PARP-1/2 inhibitor (IC50= 29-38 nM) with anti-cancer, anti-inflammatory and ischemic protective effects.
ICD inducer-2 V137780 ICD inducer-2 3069681-35-9 ICD inducer-2 is an immunogenic cell death inducer.
IDO1-IN-34 V137827 IDO1-IN-34 IDO1-IN-34 is a selective IDO1 inhibitor with an IC50 value of 0.093 μM.
INH2BP V118905 INH2BP 137881-27-7 INH2BP is a poly(ADP-ribose) polymerase (PARP) inhibitor with antioxidant and anti-apoptotic activities.
INO-1001 mesylate V94626 INO-1001 mesylate 501364-91-6 INO-1001 mesylate is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor.
iRucaparib-TP3 V115592 iRucaparib-TP3 2410557-01-4 iRucaparib-TP3 is a selective PARP1 degrader (DC50 = 36 nM).
Isoegomaketone V138125 Isoegomaketone 34348-59-9 Isoegomaketone is an orally effective apoptosis inducer and radiosensitizer.
Itareparib V138182 Itareparib 1606995-47-4 Itareparib is a PARP inhibitor with antitumor activity.
iVeliparib-AP6 V138208 iVeliparib-AP6 2472645-27-3 iVeliparib-AP6 is a Veliparib-based proteolytic targeting chimeric (PROTAC) molecule that targets PARP1/2.
JW 55 V2848 JW 55 664993-53-7 JW 55 is a potent and selective small molecule inhibitor of β-catenin signaling pathway, it functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2) which are regulators of the β-catenin destruction complex.
KMR-206 V117136 KMR-206 2992741-10-1 KMR-206 is a highly effective and selective PARP7 inhibitor with an IC50 value of 13.7 nM.
KU-0058948 hydrochloride V86184 KU-0058948 hydrochloride 2108829-86-1
Lerzeparib V56029 Lerzeparib 2459693-01-5 Lerzeparib is an (ADP-ribose) polymerase (PARP) inhibitor (antagonist) with anti-tumor activity.
LIB3S0280 V138850 LIB3S0280 LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM.
Lotixparib V139030 Lotixparib 2640677-63-8 Lotixparib is a poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor.
LS-75 V101377 LS-75 885-70-1 LS-75 is a blood-brain permeable PARP-1 inhibitor with IC50 of 18 μM.
LT-626 V111097 LT-626 1207456-03-8 LT-626 is a potent PARP inhibitor with an IC50 value of 1.60 nM.
MAPK-IN-5 V139434 MAPK-IN-5 2579683-39-7 MAPK-IN-5 is a potent MAPK inhibitor with an IC50 value of 1.35 μM against HeLa cells.
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