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PARP

PARP

PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).

PARP related products

Structure Cat No. Product Name CAS No. Product Description
PARP-1/Proteasome-IN-1 V81045 PARP-1/Proteasome-IN-1 PARP-1/Proteasome-IN-1 (compound 42i) is a dual (bifunctional) inhibitor of PARP-1 and proteasome, which has a significant inhibitory effect on breast cancer.
PARP-2-IN-2 V51277 PARP-2-IN-2 2915651-00-0 PARP-2-IN-2 (compound 27) is an inhibitor PARP‑2 with an IC50 value of 0.057 µM. In MCF-7 breast cancer cells, PARP-2-IN-2 causes cell cycle arrest and apoptosis.
PARP-2/1-IN-2 V51276 PARP-2/1-IN-2 912444-01-0 PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a novel PARP inhibitor with Kis values of 2 and 5 nM against PARP-2 and PARP-1, respectively.
PARP/EZH2-IN-1 V51283 PARP/EZH2-IN-1 2687273-52-3 PARP/EZH2-IN-1 is the first dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA that has been found to be effective.
PARP/HDAC-IN-1 V84872 PARP/HDAC-IN-1
PARP1-IN-15 V80290 PARP1-IN-15 PARP1-IN-15 (Compound 6) is a PARP1 inhibitor.
PARP1-IN-16 V81047 PARP1-IN-16 PARP1-IN-16 (compound 12a) is a potent PARP1 inhibitor (antagonist) with IC50 of 1.89 nM.
PARP1-IN-17 V79059 PARP1-IN-17 PARP1-IN-17 is a PARP-1 inhibitor (PARP-1 IC50 = 19.24 nM, PARP-2 IC50 = 32.58 nM) and can cause apoptosis.
PARP1-IN-18 V85166 PARP1-IN-18 2958609-64-6
PARP1-IN-19 V84889 PARP1-IN-19 2756337-27-4
PARP1-IN-20 V88726 PARP1-IN-20 2659357-95-4 PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1 with IC50 of 4.62 nM and has similar low PARP trapping effect compared to Veliparib, IC50 (MDA-MB-436) >100 μM.
PARP1-IN-21 V88734 PARP1-IN-21 2855979-51-8 PARP1-IN-21 (example 16) is a potent inhibitor of PARP1 with IC50 of < 10 nM.
PARP1-IN-22 V88731 PARP1-IN-22 3033649-17-8 PARP1-IN-22 (compound 15) is a potent inhibitor of PARP1 with IC50 of < 10 nM.
PARP1-IN-28 V99611 PARP1-IN-28 2855059-11-7 PARP1-IN-28 (Compound 1) is an inhibitor of PARP1.
PARP1-IN-29 V96683 PARP1-IN-29 1567375-93-2 PARP1-IN-29 is an oral PARP-1 inhibitor with IC50 of 6.3 nM.
PARP1-IN-30 V96674 PARP1-IN-30 908803-38-3 PARP1-IN-30 (compound 3) is a specific and potent PARP1 inhibitor with cytotoxicity.
PARP1-IN-33 V104017 PARP1-IN-33 2640677-68-3 PARP1-IN-33 (Example 6) is a PARP1 inhibitor (IC50: 0.41 nM).
PARP1-IN-35 V104555 PARP1-IN-35 PARP1-IN-35 (compound T26) is a selective, orally active, blood-brain permeable PARP1 inhibitor with IC50 values of 0.2 and 122 nM for PARP1 and PARP2, respectively.
PARP1-IN-5 V41042 PARP1-IN-5 2735645-53-9 PARP1-IN-5 is a low-toxic, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM).
PARP1-IN-5 dihydrochloride V41043 PARP1-IN-5 dihydrochloride 2823308-89-8 PARP1-IN-5 dihydrochloride is a novel inhibitor of PARP-1 (IC50 =14.7 nM).
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