A molecule known as a DNA alkylator or crosslinker can alkylate DNA or form a crosslink with DNA. The effects of a DNA alkylator or crosslinker can be mutagenic, therapeutic, or other. Transferring an alkyl group from one molecule to another is known as alkylation. The alkyl group can be transferred as a free radical, a carbanion, a carbene, or an alkyl carbocation.Alkyl groups are probably the most frequent group found in organic molecules, so alkylating agents are frequently used in chemistry. When there isn't a readily accessible biological precursor, selective alkylation—adding pieces of the chain with the desired functional groups—is used. Methylation is the name for alkylation with one carbon. Chemotherapy in medicine employs DNA alkylation to harm cancer cells' DNA. Alkylating antineoplastic agents are a class of medications that cause alkylation.When different exogenous or endogenous agents react with two different positions in the DNA, crosslinking of the DNA results. This can happen within the same strand of the DNA (intrastrand crosslink) or between the DNA strands (interstrand crosslink). Protein and DNA can crosslink with one another. Crosslinks prevent DNA from replicating, which stops replication and results in cell death if the crosslink is not repaired. The RAD51 family is involved in maintenance.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V50952 | Busulfan-D8 | 116653-28-2 | Busulfan-d8 is a deuterated form of Busulfan. |
|
V3530 | Satraplatin | 129580-63-8 | Satraplatin (formerly JM-216; BMS-182751; JM216; BMS182751) is a DNA alkylating agent and the firstoral platinum analog with antitumor activity. |
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