A molecule known as a DNA alkylator or crosslinker can alkylate DNA or form a crosslink with DNA. The effects of a DNA alkylator or crosslinker can be mutagenic, therapeutic, or other. Transferring an alkyl group from one molecule to another is known as alkylation. The alkyl group can be transferred as a free radical, a carbanion, a carbene, or an alkyl carbocation.Alkyl groups are probably the most frequent group found in organic molecules, so alkylating agents are frequently used in chemistry. When there isn't a readily accessible biological precursor, selective alkylation—adding pieces of the chain with the desired functional groups—is used. Methylation is the name for alkylation with one carbon. Chemotherapy in medicine employs DNA alkylation to harm cancer cells' DNA. Alkylating antineoplastic agents are a class of medications that cause alkylation.When different exogenous or endogenous agents react with two different positions in the DNA, crosslinking of the DNA results. This can happen within the same strand of the DNA (intrastrand crosslink) or between the DNA strands (interstrand crosslink). Protein and DNA can crosslink with one another. Crosslinks prevent DNA from replicating, which stops replication and results in cell death if the crosslink is not repaired. The RAD51 family is involved in maintenance.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V106078 | Dehydromonocrotaline | 23291-96-5 | Dehydromonoterpenoids (monoterpenoid pyrroles) are metabolites of monoterpenoids. |
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V55759 | DNA crosslinker 1 dihydrochloride | 2761734-27-2 | DNA crosslinker 1 (dihydrochloride) is a novel DNA minor groove binder with a binding affinity (ΔTm) to DNA of 1.1 °C. |
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V52167 | DNA crosslinker 2 dihydrochloride | 2761734-25-0 | DNA crosslinker 2 (dihydrochloride) is a selective DNA minor groove binder with a binding affinity (ΔTm) to DNA of 1.2 °C. |
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V55760 | DNA crosslinker 3 dihydrochloride | 2761734-21-6 | DNA crosslinker 3 (dihydrochloride) (compound 1) is a DNA minor groove binder with a binding affinity (ΔTm) to DNA of 1.4 °C. |
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V52166 | DNA crosslinker 4 dihydrochloride | 2761734-23-8 | DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. |
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V135090 | Endonuclease VIII | 118390-70-8 | Endonuclease VIII is a DNA repair enzyme that removes oxidized pyrimidines from DNA. |
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V115891 | FK 973 | 114580-45-9 | FK 973 is a dihydrobenzoxazine anticancer drug. |
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V112321 | Galarubicin hydrochloride | 140637-82-7 | Galararubicin hydrochloride (DA 125) is a novel anthracycline derivative. |
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V21870 | GSK3117391 | 1018673-42-1 | HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor. |
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V56577 | Ifosfamide-d4 (Ifosfamide d4) | 1189701-13-0 | Ifosfamide-d4 is the deuterium labelled form of Ifosfamide. |
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V138000 | IOB-82 | 5977-35-5 | IOB-82 is a bifunctional alkylating agent. |
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V23165 | KCC 07 | 315702-75-1 | KCC 07 is an MBD2 (Methyl-CpG-binding domain protein 2) inhibitor that prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. |
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V55756 | LP-284 | 2412580-47-1 | LP-284 is an effective agent for DNA alkylation that kills solid tumors. MCL, or mantle cell lymphoma, is one blood cancer that can be studied with LP-284 because it has poor DNA repair. |
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V140866 | N-Acetoxy-IQ | 115722-78-6 | N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to DNA, especially guanine residues. |
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V93833 | N-Butyl-N-(4-hydroxybutyl)nitrosamine | 3817-11-6 | N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that causes high levels of mutagenesis in bladder epithelial cells (urothelium). |
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V100120 | N-Sulfosuccinimidyl iodoacetate sodium | #N/A | |
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V141395 | Nitro-Naphthalimide-C2-acylamide | 2097636-43-4 | Nitro-Naphthalimide-C2-acylamide is a DNA intercalating agent. |
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V104677 | NNISC-2 | 2097636-47-8 | NNISC-2 (compound 4) is a DNA intercalator-linker conjugate of Naph-Se-TMZ, which consists of the DNA intercalator (blue part) nitronaphthalene diimide-C2-amide and a molecular linker (black part). |
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V41073 | OBI-3424 (TH-3424) | 2097713-68-1 | OBI-3424 (TH-3424) is a precursor that is selectively converted to a potent DNA alkylating agent by AKR1C3 (aldehyde-keto reductase 1C3). |
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V142275 | PBD dimer-4 | 1821339-88-1 | PBD dimer-4 is a C1-substituted PBD dimer. |
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