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PLK

PLK

Polo-like Kinases (PLKs) are a family of highly conserved serine/threonine protein kinases that are essential for a variety of biological functions, including cell division and mitosis checkpoint regulation. Five PLKs (PLK 1-5) play a variety of roles in DNA damage response, intra-S-phase and G2/M checkpoints, spindle formation, and centrosome dynamics in mammals.

PLKs are distinguished by their Polo-box domain, which mediates protein interactions. Depending on the biological context, they are also regulated by transcription, proteolysis, and phosphorylation. PLKs are now understood to function in differentiated cells and link cell division to developmental processes.

PLK related products

Structure Cat No. Product Name CAS No. Product Description
IIP0943 V137856 IIP0943 3040106-93-9 IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 value of 5.1 nM against PLK1.
MLN0905 V1578 MLN0905 1228960-69-7 MLN0905 (MLN-0905; MLN 0905) is a novel, potent and selective small-molecule inhibitor of polo-like kinase-1 (PLK1) with potential antineoplastic activity.
p53-Y220C/PLK1 modulator-1 V142089 p53-Y220C/PLK1 modulator-1 3114732-99-6 p53-Y220C/PLK1 modulator-1 is a dual modulator targeting both p53-Y220C and PLK1.
PLK1-IN-10 V88743 PLK1-IN-10 2991469-21-5 PLK1-IN-10 (Compound 4Bb) is an orally available PLK1 PBD (polo-box domain) inhibitor.
PLK1-IN-11 V142851 PLK1-IN-11 73663-97-5 PLK1-IN-11 is a PLK1 inhibitor with an IC50 of 1 μM.
PLK1-IN-12 V142852 PLK1-IN-12 PLK1-IN-12 is a highly selective, orally effective PLK1 inhibitor with an IC50 value of 20 nM.
PLK1-IN-14 V142854 PLK1-IN-14 PLK1-IN-14 is a selective PLK1 inhibitor.
PLK1-IN-15 V142855 PLK1-IN-15 3068529-37-0 PLK1-IN-15 is a PLK1 inhibitor (IC50: 38.5 nM).
PLK1-IN-16 V142856 PLK1-IN-16 3068378-51-5 PLK1-IN-16 is a selective Polo-like kinase 1 (PLK1) inhibitor with an IC50 value of 0.25 nM.
PLK1-IN-2 V55106 PLK1-IN-2 2640254-52-8 PLK1-IN-2 is a PLK1 kinase inhibitor (antagonist) with IC50 of 0.384 μM.
PLK1-IN-5 V55107 PLK1-IN-5 1001343-34-5 PLK1-IN-5 is a potent PLK1 inhibitor (antagonist) with IC50 < 500 nM.
PLK1-IN-7 V75966 PLK1-IN-7 2938910-96-2 PLK1-IN-7 (compound 30e) is a potent inhibitor of PLK1 with IC50 of 0.66 nM.
PLK1-IN-8 V85855 PLK1-IN-8
PLK1-IN-9 V88746 PLK1-IN-9 893772-67-3 PLK1-IN-9 (Compound M2) is a polo-like kinase 1 (PLK1) inhibitor that inhibits PLK protein modified by peptide 1010pT, cdc25c, and PBIP with IC50 of 1.6, 0.8, and 1.4 μM, respectively.
PLK1/PRC1-IN-1 V142850 PLK1/PRC1-IN-1 2991469-28-2 PLK1/PRC1-IN-1 is an inhibitor of PLK1/PRC1 protein complex formation.
PLK1抑制剂onvansertib(PCM-075) V1580 NMS-P937 (NMS1286937; Onvansertib) 1034616-18-6 NMS-P937 (also know as NMS-P937;NMS1286937;NMS-P-937; NMS-P 937; Onvansertib) is an orally bioavailable, potent, selective, small-molecule Polo-like Kinase 1 (PLK1) inhibitor with potential antitumor activity.
PLK2 Recombinant Human Active Protein Kinase V116561 PLK2 Recombinant Human Active Protein Kinase PLK2 belongs to the Polo-like kinase (PLK) family, which includes five mammalian members and plays a central role in the cell cycle and related events.
PLK4-IN-1 V55108 PLK4-IN-1 1247001-12-2 PLK4-IN-1 (Example A6) is an inhibitor (blocker/antagonist) of PLK4 with IC50 of ≤ 0.1 μM.
PLK4-IN-3 V55109 PLK4-IN-3 1247001-86-0 PLK4-IN-3 is the absolute configuration of PLK4-IN-1.
PLK4-IN-4 V84180 PLK4-IN-4 2923999-01-1
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