G-quadruplex

G-quadruplex

G-Quadruplex nucleic acids or G-quadruplexes (G4s) are four-stranded DNA or RNA secondary structures that are formed in guanine-rich sequences.The fact that G-quadruplex structures are widely distributed in the human genome's functional regions, including telomeres, ribosomal DNA (rDNA), transcription start sites, promoter regions, and untranslated regions of mRNA, suggests that they may be crucial in the regulation of a number of cellular processes. In the regulatory regions of microbes, such as bacteria, fungi, and viruses, G4s are also enriched and conserved.

Cancer and neurodegenerative diseases may be brought on by the erroneous formation of G4s on some genes. As a result, the therapeutic targets for these diseases are G4s in the genome. Small molecules, both natural and synthetic, are used to target G-quadruplexes specifically and have emerged as a new class of anticancer drugs.

G-quadruplex related products

Structure Cat No. Product Name CAS No. Product Description
V79018 Antitumor agent-84 Antitumor agent-84 (compound 21a) is a G-quadruplex (G4) ligand with the ability to stabilize different G4-DNA structures.
V79009 Antitumor agent-85 Antitumor agent-85 is a G-quadruplex (G4) ligand with the ability to stabilize different G4-DNA structures.
V54460 Carboxy pyridostatin trifluoroacetate salt 2444713-88-4 Carboxy pyridostatin trifluoroacetate salt displays high molecular specificity for RNA on DNA G4s.
V52175 DIZ-3 2675490-72-7 DIZ-3 is a selective multimeric G4 ligand based on a G4 ligand dimerization strategy.
V4151 Nemorubicin 108852-90-0 Nemorubicin (also known as PNU152243A; Methoxymorpholinyldoxorubicin; PNU 152243; PNU-152243A), an analog of doxorubicin, is a DNA-intercalator, topoisomerase and RNA synthesis inhibitor that was undergoing development for cancer treatment.
V32259 Pyridostatin hydrochloride 1781882-65-2 Pyridostatin HCl (RR82) is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.
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