APC (Anaphase-Promoting Complex) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome.APC/C is a substantial protein complex that consists of 11–13 subunits, including a cullin (Apc2) and RING (Apc11) subunit that is similar to SCF. The primary role of the APC/C is to signal the change from metaphase to anaphase by designating particular proteins for degradation. Securin and S and M cyclins are the two crucial proteins that are broken down in this procedure as substrates of the APC/C.After being broken down, securin releases separase, a protease, which in turn causes cohesin, the protein complex that holds sister chromatids together, to be cleaved. Sister chromatids are connected by intact cohesin complexes during metaphase. Sister chromatids can move to opposing poles for anaphase when securin is subjected to ubiquitination by the APC/C and releases separase, which breaks down cohesin. The M-CdK (mitotic cyclin-dependent kinase) complexes are inactivated as a result of the APC/C'stargetingof the mitotic cyclins for degradation, promoting exit from mitosis and cytokinesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V11261 | Apcin | 300815-04-7 | Apcin is a ligand of Cdc20 and a potent and competitive inhibitor of the E3 ligase activity anaphase-promoting complex/cyclosome (APC/C). |
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V2250 | Apcin A | 1683617-62-0 | Apcin-A, an Apcin analogue, is an inhibitor (blocker/antagonist) of the anaphase promoting complex (APC). |
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V1321 | TAME | 901-47-3 | TAME (Tosyl-L-Arginine Methyl Ester) is a potent small molecule APC (anaphase-promoting complex/cyclosome) inhibitor, which can target proteins for degradation and cause chromatid separation. |
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