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Btk

Btk

Bruton tyrosine kinase (Btk) is a member of the Tec family kinases with a well-characterized role in B-cell antigen receptor (BCR)-signaling and B-cell activation.Btk is a new target for diseases with abnormal B cell activity because it is essential for B cell development and activation through the BCR signaling pathway. The human primary immune deficiency disease X-linked agammaglobulinemia (XLA), which is caused by a mutation in the Btk gene, highlights the importance of Btk, a kinase that is only expressed in B cells and myeloid cells. The BCR signaling pathway depends on Btk in many ways.B cell receptor oligomerization, Syk and Lyn kinase activation, and Btk kinase activation are all caused by antigen binding to the BCR. When Btk is activated, it joins forces with proteins like BLNK, Lyn, and Syk to form a signaling complex that phosphorylates phospholipase C (PLC)2. This results in transcriptional changes that promote B cell survival, proliferation, and/or differentiation by releasing intracellular Ca2+ stores downstream and propagating the BCR signaling pathway through extracellular signal-regulated kinase and NF-B signaling.

Btk related products

Structure Cat No. Product Name CAS No. Product Description
BTK-IN-15 V69687 BTK-IN-15 2820426-92-2 BTK-IN-15 is a novel Bruton's tyrosine kinase (BTK) inhibitor (antagonist) with good oral activity.
BTK-IN-16 V69675 BTK-IN-16 2883232-92-4 BTK-IN-16 is an inhibitor (blocker/antagonist) of the BTK wild type and C481S mutant of Bruton's tyrosine kinase (BTK), with IC50s of 5.1 and 4.1 μM respectively.
BTK-IN-17 V78823 BTK-IN-17 BTK-IN-17 (compound 36R) is a selective BTK inhibitor (antagonist) with IC50 of 13.7 nM.
BTK-IN-18 V69690 BTK-IN-18 1374239-71-0 BTK-IN-18 is a potent, reversible BTK inhibitor (antagonist) with IC50 of 0.002 µM.
BTK-IN-19 V69692 BTK-IN-19 1374240-01-3 BTK-IN-19 (Compound 51) is a reversible BTK inhibitor (antagonist) with IC50 <0.001 μM.
BTK-IN-20 V69696 BTK-IN-20 1581714-50-2 BTK-IN-20 (compound 283) is a BTK tyrosine kinase inhibitor and 1H-pyrazolo[3,4-d]pyrimidine analogue.
BTK-IN-22 V69688 BTK-IN-22 2573048-10-7 BTK-IN-22 is a BTK inhibitor (IC50= 12.8 nM).
BTK-IN-23 V69695 BTK-IN-23 2573048-11-8 BTK-IN-23 is a BTK inhibitor (IC50= 12.8 nM).
BTK-IN-25 V69701 BTK-IN-25 2562351-92-0 BTK-IN-25 (compound 71) is a potent BTK inhibitor against BTK(C481S) with IC50 of 0.77 nM.
BTK-IN-26 V69676 BTK-IN-26 2762043-61-6 BTK-IN-26 (compound 18) is a potent inhibitor of Bruton's tyrosine kinase (BTK) and its C481 mutant, with IC50s of 0.7 and 0.8 nM for BTK and BTK C481S, respectively.
BTK-IN-27 V69693 BTK-IN-27 1841502-36-0 BTK-IN-27 (example 8) is a BTK inhibitor (IC50= 0.2 nM).
BTK-IN-28 V79868 BTK-IN-28 BTK-IN-28 (compound PID-4) is a potent BTK inhibitor (antagonist) with anti-cancer activity.
BTK-IN-29 V85507 BTK-IN-29 2736508-60-2
BTK-IN-3 V84306 BTK-IN-3 1226872-27-0
BTK-IN-30 V85502 BTK-IN-30 2662512-15-2
BTK-IN-31 V85791 BTK-IN-31 2662512-02-7
BTK-IN-32 V85253 BTK-IN-32 1015441-29-8
BTK-IN-33 V85343 BTK-IN-33 2765854-31-5
BTK-IN-34 V83518 BTK-IN-34 3016419-52-3
BTK-IN-5 V69674 BTK-IN-5 2145152-06-1 BTK-IN-5 is a covalent BTK inhibitor used to study diseases like cardiovascular disease, respiratory disease, inflammation and diabetes.
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