MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases.The metzincin superfamily of proteases, to which the MMPs belong, is a larger group of enzymes. MMPs can process a variety of bioactive molecules in addition to breaking down various extracellular matrix proteins. They have been linked to the inactivation of chemokines and cytokines as well as the cleavage of cell surface receptors and the release of apoptotic ligands. Additionally, it is believed that MMPs have a significant impact on the proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense of cells.It is believed that MMP-2 and MMP-9 are crucial for metastasis. MMP-1 is regarded as being significant in osteoarthritis and rheumatoid arthritis. Recent research indicates that MMPs are actively involved in the pathogenesis of aortic aneurysms. The structural proteins of the aortic wall are degraded by excess MMPs. Acute and chronic cardiovascular diseases both exhibit dysregulation of the balance between MMPs and TIMPs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0735 | Batimastat (BB94) | 130370-60-4 | Batimastat (formerly known as BB-94), asynthetic hydroxamate analog and an anticancer drug developedby Laurie Hines of British Biotech,is a broad spectrum inhibitor of matrix metalloprotease (MMP) with potential antitumor activity. |
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V0737 | Ilomastat (GM6001, Galardin) | 142880-36-2 | Ilomastat (GM-6001; GM6001;Galardin),a member of the hydroxamic acid class of reversible metallopeptidase inhibitors with important biological activity,isa potent, synthetic, and broad spectrum matrix metalloprotease (MMP) inhibitor. |
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V2084 | JNJ0966 | 315705-75-0 | JNJ0966 is a novel, potent and highly selective allosteric inhibitor of MMP-9 (matrix metalloproteinase-9) zymogen with an IC50 of 440 nM. |
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V0739 | Marimastat (BB-2516) | 154039-60-8 | Marimastat (formerly aslo known as BB2516; BB-2516; TA2516; TA-2516) is an orally bioactive and broad spectrum matrix metalloprotease (MMP) inhibitorwith potential anticancer activity. |
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V37650 | MMP-9-IN-1 | 502887-71-0 | MMP-9-IN-1 is a novel, potent and selective matrix metalloproteinase-9 (MMP-9) inhibitor that is able to inhibit tumor growth and metastasis by reducing cell migration and proliferation. |
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V0738 | Nobiletin | 478-01-3 | Nobiletin (Hexamethoxyflavone; NOB), a naturally occurring flavonoid compound isolated from citrus peels like in tangerine and the Chinese drug chen-pi, has anti-inflammatory and anti-tumor activities. |
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V0736 | NSC 405020 | 7497-07-6 | NSC 405020 (NSC405020; NSC-405020) is a novel small molecule inhibitor of MT1-MMP (Membrane type-1 matrix metalloproteinase) that targets thenoncatalytic domain of MMP with potential antineoplastic activity. |
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V0740 | SB-3CT | 292605-14-2 | SB-3CT (SB 3CT) is a non-selective and covalent inhibitor of gelatinases/matrix metalloproteinase (MMP) with potential antineoplastic activity. |
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V4258 | T-26c | 869296-13-9 | T-26c is a novel, highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with an IC50 of 6.75 pM and shows more than 2600-fold selectivity over the other related metalloenzymes. |
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V1927 | TAPI-1 | 171235-71-5 | TAPI-1 is an ADAM17/TACE(TNF-α-converting enzyme) inhibitor with thepotential to be used as a therapeutic agent for kidney injury. |
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