Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V85829 | Anticancer agent 175 | ||
|
V84948 | Antitumor agent-132 | ||
|
V116738 | Arvelexin | 4837-74-5 | Avelixin is a biologically active compound found in plants of the genus Brassica rapa L. (Brassica family). |
|
V82267 | Asperlactone | 76375-62-7 | Asperlactone exhibits anti-inflammatory effect. |
|
V89730 | Avenanthramide-C methyl ester | 955382-52-2 | Avenanthramide-C methyl ester is an anti-inflammatory agent and NF-κB inhibitor that inhibits the secretion of proinflammatory factors. |
|
V82266 | Banksialactone A | 1135775-06-2 | Banksialactone A is a metabolite of the Australian fungus Aspergillus bankianus. |
|
V4192 | Bay 65-1942 HCl | 600734-06-3 | Bay 65-1942 HCl is the hydrochloride salt of of BAY65-1942 which is a novel, potent and selective ATP-competitive inhibitor ofIKKβ. |
|
V82269 | Beauveriolide I | 154491-55-1 | Beauveriolide I is a metabolite of the entomopathogenic fungus Beauveria sp. |
|
V84593 | biKEAP1 | ||
|
V82274 | Bisphenol A-d16 (bisphenol A-d16) | 96210-87-6 | Bisphenol A-d16 is the deuterium labelled form of Bisphenol A. |
|
V82273 | Bisphenol A-d4-1 (bisphenol A-d4-1) | 347841-41-2 | Bisphenol A-d4-1 is the deuterated form of Bisphenol A. |
|
V82272 | Bisphenol A-d6 (bisphenol A d6) | 86588-58-1 | Bisphenol A-d6 is the deuterium labelled form of Bisphenol A. |
|
V82276 | Bisphenol A-d8 (bisphenol A-d8) | 92739-58-7 | Bisphenol A-d8 is a phenolic organic synthetic compound extensively used in the production of polycarbonate plastics and epoxy resins. |
|
V107829 | BPD | 213481-12-0 | BPD is a COX-2 and TAK1-NF-κB inhibitor with IC50 of 18.5 μM for COX-2. |
|
V17405 | C25-140 | 1358099-18-9 | C25-140 (C-25140;C25140) is a novel, first-in-class and potent inhibitor of RING-E3 ligase (TRAF6) / E2 enzyme (Ubc13) protein-protein interaction (PPI) with potential use forautoimmune and chronic inflammatory diseases. |
|
V103069 | cAIMP | 1507367-51-2 | cAIMP (cyclic adenosine-inosine monophosphate) is a potent synthetic cyclic dinucleotide. |
|
V82254 | Cannabidiorcol (O-1821; CBD-C1) | 35482-50-9 | Cannabidiorcol (CBDO, CBD-C1, O-1821) an analogue of cannabidiol with its pentyl side chain shortened to a methyl group. |
|
V83482 | CAY10512 | 139141-12-1 | |
|
V101720 | CAY10657 | 494772-86-0 | CAY10657 is an inhibitor of the NF-κB pathway that can downregulate the expression of proinflammatory cytokines (IL-6) and chemokines (MCP-1), thereby exerting an anti-inflammatory effect on Streptococcus suis-induced meningitis. |
|
V3172 | CBL0137 | 1197996-80-7 | CBL0137 (formerly known as Curaxin 137 or CBL-0137) is an inhibitor of the histone chaperone,FACT (facilitates chromatin transcription complex). |
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