IKK is a complex composed of three subunits: IKKα, IKKβ, and IKKγ (also called NEMO).The complex serves as the center of signal integration for activating NF-B. In order to catalyze the phosphorylation of numerous I-B and NF-B proteins as well as other substrates, it combines signals from all NF-B activating stimuli. The IKKs IKK-alpha and IKK-beta, as well as the IKK-related kinases TBK1 and IKK-epsilon, make up the four members of the human IKK family.
The so-called canonical members, IKK-1 and IKK-2, phosphoryate I-B, activating the transcription factor NF-B, which in turn regulates the expression of several immunological and inflammatory genes. IRF3, a distinct substrate of the IKK-related proteins TBK-1 and IKK-epsilon, controls a separate set of genes, the byproducts of which include Type I interferons. Due to their critical roles in numerous biological processes, such as the immunological response, the stress response, and tumor growth, IKKs are a therapeutic target.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V120132 | TBK1 ligand 2-CO-C4-O-C3-OC-amide | 2052306-12-2 | TBK1 ligand 2-CO-C4-O-C3-OC-amide is a conjugate of TBK1 ligand and linker, which can be used to synthesize PROTAC TBK1 degrader-2. |
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V145643 | TBK1 ligand 3 | 2115897-10-2 | TBK1 ligand 3 is a TBK1 ligand that can be used as a target protein ligand for the synthesis of PROTAC UNC8209 and UNC8461. |
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V116629 | TBK1 Recombinant Human Active Protein Kinase | TBK1 is a member of the IκB kinase (IKK) family and is widely expressed. | |
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V51258 | TBK1-IN-1 | TANK binding kinase 1 (TBK1) inhibitor | |
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V145644 | TBK1-IN-2 | 3075572-35-6 | TBK1-IN-2 is a potent TBK1 inhibitor (IC50: 775 pM). |
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V3366 | TBK1/IKKε-IN-1 | 1292310-49-6 | TBK1/IKKε-IN-1 is a novel, potent dualTBK1andIKKεinhibitor with potential anticancer activity. |
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V51260 | TBK1/IKKε-IN-1 | 2058264-32-5 | dual TBK1 and IKKε inhibitor |
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V32070 | TBK1/IKKε-IN-5 | 1893397-65-3 | TBK1/IKKε-IN-5 (compound 1 in patent WO 2016049211) is a potent dual TBK1 and IKKε inhibitor, with IC50 of 1 nM and 5.6 nM for TBK1 and IKKε, respectively. |
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V51259 | TBK1/IKKε-IN-6 | 2306877-20-1 | dual TBK1 and IKKε inhibitor |
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V0751 | TPCA-1 (GW-683965; GW683965) | 507475-17-4 | TPCA-1 (also known as TPCA1; GW-683965; GW683965)is novel, potent, and selective inhibitor of IKK-2 with potential anti-inflammatory activity. |
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V0759 | WS6 | 1421227-53-3 | WS6 (WS6; WS 6) is a novel and potent small molecule modulator of β cell proliferation via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway with important biological activity. |
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V0758 | WS3 | 1421227-52-2 | WS-3 (WS3; WS 3) is a novel and potent small molecule modulatior of Erb3 binding protein-1 (EBP1) and the IκB (IkappaB) kinase with important biological activity. |
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V7554 | Dehydrocostus Lactone | 477-43-0 | Dehydrocostus Lactone is a major class of sesquiterpene lactones extracted from Amaranthus aeruginosa. |
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V11455 | Amlexanox (AA673; CHX3673) | 68302-57-8 | Amlexanox (Amoxanox; AA-673; CHX-3673) is a potent and selective IKKε and TBK1 inhibitor which acts asanti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. |
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V0762 | Mesalamine (5ASA; 5-aminosalicylic acid; Asacol; mesalazine; 5-ASA) | 89-57-6 | Mesalamine (also named as5ASA; Z-206; AJG-501; MAX-002; 5-aminosalicylic acid; Asacol;mesalazine; 5-ASA) is a specific and orally bioavailableinhibitor of TNFα-induced IKK activity with potential anti-inflammatory activity. |
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V0754 | Bardoxolone Methyl | 218600-53-4 | Bardoxolone Methyl (also called NSC 713200; NSC-713200;RTA 402;RTA-402 and CDDO-methyl ester) is a novel, potent, orally bioavailable IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. |
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