IKK is a complex composed of three subunits: IKKα, IKKβ, and IKKγ (also called NEMO).The complex serves as the center of signal integration for activating NF-B. In order to catalyze the phosphorylation of numerous I-B and NF-B proteins as well as other substrates, it combines signals from all NF-B activating stimuli. The IKKs IKK-alpha and IKK-beta, as well as the IKK-related kinases TBK1 and IKK-epsilon, make up the four members of the human IKK family.
The so-called canonical members, IKK-1 and IKK-2, phosphoryate I-B, activating the transcription factor NF-B, which in turn regulates the expression of several immunological and inflammatory genes. IRF3, a distinct substrate of the IKK-related proteins TBK-1 and IKK-epsilon, controls a separate set of genes, the byproducts of which include Type I interferons. Due to their critical roles in numerous biological processes, such as the immunological response, the stress response, and tumor growth, IKKs are a therapeutic target.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V87868 | IKKβ-IN-4 | 4815-35-4 | IKKβ-IN-4 (compound 14) is an IkappaB kinase-β (ikkβ) inhibitor with IC50 of 1.9 μM. |
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V110747 | IKKβ-IN-5 | IKKβ-IN-5 is an orally effective selective IKKβ inhibitor with an IC50 value of 7.5 nM. | |
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V137862 | IKKε-IN-1 | 3035441-37-0 | IKKε-IN-1 is an IKKε inhibitor. |
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V0752 | IMD 0354 | 978-62-1 | IMD-0354 (IMD0354; IMD-0354) is a novel, potent and selective IKKβ inhibitorwith potential anti-inflammatory activity. |
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V4604 | INH-14 | 200134-22-1 | INH14 is a novel, potent and cell permeable inhibitor ofIKKα/IKKβ, withIC50s of 8.97 and 3.59 μM, respectively. |
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V116720 | ITA-5 | 2374162-36-2 | ITA-5 is an itaconic acid-based TBK1 inhibitor. |
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V116458 | ITA-9 | ITA-9 is an itaconic acid-based TBK1 inhibitor. | |
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V82228 | Keap1-Nrf2-IN-7 | 2769963-42-8 | Keap1-Nrf2-IN-7 (compound 7v) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor (antagonist) with IC50 of 0.45 µM. |
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V82225 | Keap1-Nrf2-IN-8 | 2769963-54-2 | Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor (antagonist) with IC50 of 64.5 nM and 14.2 nM in FP and TR-FRET assays, respectively. |
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V119086 | LLVK | 798540-36-0 | LLVK is a selective IκB phosphorylation inhibitor. |
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V118451 | LLVK TFA | LLVK TFA is a selective IκB phosphorylation inhibitor. | |
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V0757 | LY2409881 trihydrochloride | 946518-60-1 | LY2409881trihydrochloride (LY-2409881; LY 2409881), thetrihydrochloride salt of LY-2409881, is a novel, potent and selective IKK2 (IκB kinase β) inhibitor with potential anticancer and anti-inflammatory activity. |
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V4027 | MLN120B | 783348-36-7 | MLN120B (MLN-120B) is a novel, potent, specific and ATP competitiveIKKβ (IκB kinase beta subunit) inhibitor with anti-inflammatory activity. |
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V2438 | NF-κB-IN-1 | 1227098-15-8 | NF-κB-IN-1, a 4-arylene curcumin analog, is a potent inhibitor of the NF-κB signaling pathway. |
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V0753 | PS-1145 | 431898-65-6 | PS-1145 (PS1145) is a novel, potent and specific IKK (IκB kinase) inhibitor with anticancer activity. |
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V82226 | Resolvin D1-d5 (RvD1-d5) | 1881277-32-2 | Resolvin D1-d5 is the deuterium labelled form of Resolvin D1. |
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V0761 | SC-514 | 354812-17-2 | SC-514 (SC 514; SC514) is a novel, potent, orally bioactive, selective and reversible, and ATP-competitive IKK-2 inhibitor with potential anti-inflammatory activity. |
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V112143 | SR8185 | 1356225-62-1 | SR8185 is a potent and selective dual inhibitor of TBK1/IKKi, with an IC50 value of 3 nM for IKKi and less than 10 nM for TBK1. |
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V117419 | Tat-IKIP (46-60) TFA | Tat-IKIP (46-60) TFA is the trifluoroacetate of Tat-IKIP (46-60). | |
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V120317 | TBK1 ligand 2 | 2052306-16-6 | TBK1 ligand 2 (compound 1b) is a TBK1 inhibitor. |
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