Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus.Thyroid hormone (T3)-mediated biological activities are mediated by thyroid hormone receptors, ligand-dependent transcription factors. Two genes, one for TR and the other for TR, encode the primary isoforms of thyroid hormone receptors, including TR1, TR2, TR1, and TR2. The pleiotropic effects of the thyroid hormone (T3) on growth, development, and differentiation as well as the preservation of metabolic equilibrium are mediated by the thyroid hormone receptors.
Thyroid hormone receptors are zinc finger transcription factors belonging to the erbA superfamily that bind to DNA at particular response element sequences called TREs and trigger gene expression in response to thyroid hormone (T3). It has been demonstrated that thyroid hormone receptors can form monomers, homodimers, or heterodimers with the retinoid X receptor (RXR), another member of the erbA superfamily, to bind DNA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V89103 | VK-0214 | 852949-30-5 | VK-0214 is a thyroid beta receptor (TRβ) agonist that improves X-linked adrenoleukodystrophy (X-ALD) by activating ABCD2 expression and reducing very long-chain fatty acids (VLCFA) accumulation. |
|
V15711 | Taltirelin (TA0910) | 103300-74-9 | Taltirelin(TA-0910; tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog and a TRH mimic that acts as a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). |
|
V29928 | L-Thyroxine sodium salt pentahydrate | 6106-07-6 | L-Thyroxine sodium salt pentahydrate is an endogenous iodine-bearing thyroid hormone produced from thyroglobulin in the thyroid follicular cells. |
|
V30180 | Liothyronine sodium | 55-06-1 | Liothyronine sodium is a potent thyroid hormone. |
|
V32625 | Taltirelin acetate (TA0910; Ceredist) | 1549593-23-8 | Taltirelin acetate (TA-0910; tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog and a TRH mimic that acts as a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). |
|
V3920 | ABALOPARATIDE | 247062-33-5 | Abaloparatide (Trade name Tymlos; formerly known as BA-058; ITM-058; BIM 44058) is a 34 amino acid synthetic analog of parathyroid hormone-related protein (PTHrP) that is used to treat osteoporosis. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
