ERR

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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ERR

Estrogen receptors are a group of proteins found inside cells.They are receptors that the estrogen (17-estradiol) hormone activates. There are two classes of estrogen receptors: GPER (GPR30), a member of the rhodopsin-like family of G protein-coupled receptors, and ER, a member of the nuclear hormone family of intracellular receptors. The interactions between coactivators and corepressors, and consequently, the agonist or antagonist effect of the ligand, are heavily influenced by the ER's helix 12 domain.Different ligands may have different affinities for the estrogen receptor's alpha and beta isoforms. Estradiol binds to both receptors equally well, however raloxifene, estrone, and genistein bind preferentially to the alpha receptor. In addition to being necessary for sexual maturation and reproductive function, estrogen and its receptors also affect other tissues, like bone. In pathological conditions like osteoporosis, endometrial cancer, and breast cancer, estrogen receptors play a role. Numerous transcript variations are produced by alternative promoter use and alternative splicing, however it is unknown how many of these variants are full-length.

ERR related products

Cat No.	Product Name	CAS No.	Product Description
V109501	ER ligand-14-PEG3-Boc		ER ligand-14-PEG3-Boc is a conjugate of a target protein ligand and a linker, consisting of an estrogen receptor ligand and its corresponding linker.
V108970	ERB-2		ERB-2 is a selective ERβ protein degrader.
V67721	ERRα antagonist-1	1072145-33-5	ERRα antagonist-1 (Compound A) is a selective, high-affinity estrogen-related receptor α (ERRα) antagonist.
V67719	ERRγ inverse agonist 1	2316832-86-5	ERRγ Inverse Agonist 1 (Compound 12) is a specific, orally bioactive estrogen-related receptor gamma (ERRγ) inverse agonist/activator with IC50 of 40 nM.
V67725	ERRγ inverse agonist 2	324022-01-7	ERRγ inverse agonist 2 (compound 19) is a potent and specific ERRγ inverse agonist/activator with a Kd of 6.5 μM.
V114887	ERα antagonist 2		ERα antagonist 2 (compound 5b) is an ER-α antagonist with an IC50 value of 1729 nM.
V94988	ERα degrader 10		ERα degrader 10 is a potent, selective and orally available estrogen receptor α (ERα) degrader.
V94379	ERα degrader 11	3052336-87-2	ERα degrader 11 (Compound B16) is a selective ERα degrader that can be used as an estrogen receptor probe to study the ER status in ER-positive breast cancer cells.
V116181	ERα degrader 14	2991580-03-9	ERα degrader 14 (compound B7) is a potent ERα degrader.
V67716	ERα degrader 5	2941268-96-6	ERα degrader 5 (Compound 40) is a selective, orally bioactive estrogen receptor (ER) degrader with EC50 of 1.1 nM for ERα.
V101797	ERα degrader 8	2971837-95-1	ERα degrader 8 (compound 18j) is a selective estrogen receptor degrader.
V67717	ERα degrader-2	2235396-63-9	ERα degrader-2 is a selective estrogen receptor degrader (SERD) with strong binding affinity to ERα (IC50=17.1 nM) and good degradation effect (EC50=0.3 nM).
V111034	ERα ligand 3		ERα ligand 3 is a PROTAC target protein ligand that targets ERα.
V109243	ERα ligand 4	97818-93-4	ERα ligand 4 is an ERα ligand that can be used to synthesize PROTACs, such as NEP168.
V112371	Estradiol acetate	4245-41-4	Estradiol acetate is a novel oral active estradiol prodrug.
V67702	Estradiol enanthate	4956-37-0	Estradiol enanthate is a short-acting estrogen.
V67674	Estrogen receptor antagonist 7	2889371-04-2	Estrogen receptor antagonist 7 (compound 13) is a potent estrogen receptor (ER) antagonist.
V67709	Estrogen receptor antagonist 8	2889370-92-5	Estrogen receptor blocker (antagonist) 8 is a potent estrogen receptor ER antagonist (inhibitor) with antiuterine properties in vivo (EC50=4.160 μM)
V67718	Estrogen receptor modulator 6	787621-78-7	Estrogen receptor modulator 6 (compound 3a) is a selective estrogen receptor ERβ agonist (Ki=0.44 nM).
V67677	Estrogen receptor modulator 7	2639168-13-9	Estrogen receptor modulator 7 is a potent estrogen receptor modulator.