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    CID-755673 sodium
    CID-755673 sodium

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V18319
    CAS #: N/APurity ≥98%

    Description: CID755673 sodium  (also known as benzoxoloazepinolone) is a novel, potent and selective cell-active pan-PKD1/2/3 (Protein kinase D) inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, it shows about 200-fold selectivity over other CAMKs. CID755673 is the first identified cell-active small molecule PKD antagonist. It inhibits the activity of PKD1 with an IC50 of 182 nM and demonstrates highest selectivity to PKD1 when compared with AKT, PLK1, CAK, CAMKIIα, PKD2 and PKD3. Moreover, it was not competitive with ATP for enzyme inhibition.  In HeLa cells, CID755673 significantly blocks PMA-induced nuclear export of HDAC5, and blocks PKD-mediated protein transport.

    References: J Biol Chem. 2008 Nov 28;283(48):33516-26; Front Physiol. 2012 Mar 27;3:60; Front Immunol. 2013 Mar 18;4:66.

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